This study is based on the theory of Constructivism and Scaffolding to implement a Blog system environment which allows users to create their own personalized Blog for individual, group, and organization practice. The Blog system is a platform for members to exchange their ideas and thoughts in order to achieve the goal of knowledge sharing and then enhance learning effects of the students. This study utilizes the quasi-experiment method and survey research to aim at the target sample of the e-learning related curriculum provided by the department of Information Systems. A fourteen-week experiment was conducted to explore for whether the interaction of teaching strategy and learning style based on the Constructivism and Scaffolding would enhance student learning effects. The results of two-way MANCOVA analysis reveals: (1) the learner's learning style has no significant influence on their learning effects, (2) teaching strategy based on the Constructivism and Scaffolding can improve learner's learning effects, and (3) under the interaction of teaching strategy and learning style, the experimental group shows better learning effects.