- 期刊
The Biochemical Profile of Liver Function Tests in Normal Chinese Infants and Children Ⅱ. Liver Enzymes and Serum Lipids
正常中國兒童之肝機能試驗（二）肝臟酵素與血清脂質
摘要
為明瞭與肝臟有關的血清酵素及血清脂質在正常中國兒童的發育型並建立其參考值以供臨床應用，我們以1127個15歲以下，外表健康且B型肝炎表面抗原陰性的中國兒童為對象，取其血清以Hitachi-716自動分析儀測定轉氨酶AST與ALT、鹼性磷酸酶、三甘油脂及膽固醇。使用無母數百分位法，將各單項試驗在各個年齡拿的正常範圍加以確立。分析各單項試驗的平均值與年齡、性別之關係，結果顯示：AST的平均活性在嬰兒期較高，以後隨年齡漸降，到11至14歲時呈現最低。ALT平均值均較AST為低，且在1至2歲後卽較穩定。鹼性磷酸酶之平均活性隨著年齡而有變化，12歲以後男女活生之差異特別明顯。兒童的正常值可達成人正常值上限的4倍。女生在11歲時活性最高，以後迅速下降至成人正常值範圍，而男生最高活性見於11至13歲，以後變化較緩。三甘油脂平均值在男生以12歲時之73 mg/dl最高，接著明顯降低，至14歲時達最低值；女生則自8歲至11歲間明顯增高，接著很快降至14歲時的最低值，女生通常較男生有較高的禁食後三甘油脂平均值。血清膽固醇平均值在嬰兒早期即達成人正常值的低限，4到10歲間維持變化於158至167mg/dl之間，但在11至14歲時，男女生均呈漸降的趨勢。
關鍵字
無資料並列摘要
To determine the reference ranges and developmental pattern of liver enzymes and serum lipids, serum samples of 1127 hepatitis B surface antigen (HBsAg) -negative, apparently healthy Chinese children aged from 2 days to 14 years were tested for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phoshatase (ALP), triglyceride (TG) and cholesterol (CHO) with an autoanalyzer (Hitachi Model 716, Tokyo). Reference ranges for each test were established by using a nonparametric statistical method. Mean AST activity was higher in infancy, decreased gradually in subsequent age groups and approached the lowest level at 11-14 years. Mean ALT activity was always lower and less age-dependent than AST and became more stable after one to two years of age. Age-dependent variation was observed throughout childhood for the mean ALP activity, and a sex difference occurred, particularly after 12 years of age. Peak activities in girls occurred at 11 years, followed by a sharp decline to the adult level within a few years, whereas more pronounced peak activities in boys occurred between 11-13 years without much subsequent alteration. Chinese children had ALP activities as high as four times the upper adult limit. Mean serum TG in boys varied minimally from 3 to 10 years, achieved its highest level of 73 mg/dl at 12 years, then sharply decreased through age 13 to the lowest level at 14 years. In girls, there was a sharp increment in mean TG level from age 8 to 11, followed by a rapid decline to preadolescent level at 14 years. Mean level of serum CHO reached a low adult level in early infancy, remained relatively stable from age 4-10 years, with a range from 158 to 167 mg/dl. Mean CHO concentration tended to fall in both sexes between 11 to 14 years of age.