- 期刊
Finasteride in the Treatment of Taiwanese Men with Androgenetic Alopecia: A 12-Month Open-Label Study
以finasteride治療臺灣男性雄性禿之療效：為期12個月之開放式研究
摘要
Finasteride(1 mg/天)在治療雄性禿方面已經被證實有效。此開放式研究目的在於評估finasteride對台灣男性雄性禿的療效及安全性。共有34位台灣男性雄性禿患者(18-40歲)參與。患者雄性禿之程度為modified Norwood/Hamilton scale (MNHS)第二至五級。在研究者評估方面，於第12個月時有21位接受評估，其中有5位(23.8%)為二級MNHS的進步，12位(57.1%)呈現一級的進步，其餘則維持原等級。照片評估方面，第6個月時31位中有5位(15.1%)，而第12個月時，21位中有11位(52.4%)可見頭髮的生長。整個療程中在患者自我評估頭髮生長上，所有評估項目均顯示有漸近改善的情況，而在改善程度上，第12個月皆比第6個月顯著，且第12個月時21位中有9位(42.9%)對整體頭髮外觀感到滿意。血清中攝護腺特定抗原值於第12個月時降低了23.4%。Finasteride的副作用很少，雖然34位中有5位發現肝功能異常，但其與藥物間之相關性仍無法確定。總結來說，對於台灣男性雄性禿患者，以finasteride(1mg/天)治療持續1年，可以減緩繼續掉髮，並增加頭髮的生長。
關鍵字
雄性禿並列摘要
Finasteride 1 mg / day is effective in the treatment of androgenetic alopecia (AGA). Our open-label study assessed the efficacy and safety of finasteride for the treatment of Taiwanese men with AGA. We enrolled 34 Taiwanese men (aged 18-40 yr) with AGA of modified Norwood/Hamilton scale (MNHS) grade II-V. In investigator assessments at 12 months, five of 21 subjects (23.8%) had two-grade improvement in MNHS grade and 12 of 21 subjects (57.1%) had one-grade improvement; the others remained at the same grade. In global photographic evaluation, five of 31 subjects (15.1 %) had observable hair growth at 6 months and 11 of 21 subjects (52.4 %) had observable hair growth at 12 months. Patient self-assessment of hair growth was favorable across all questions in the treatment course, more significantly at 12 months than at 6 months; nine of 21 subjects (42.9%) were satisfied with their overall appearance at 12 months. Serum prostate specific antigen levels had decreased by 23.4% at 12 months. Adverse effects, including abnormal liver function (5/34), were minimal, and the causal relationship with finasteride could not be established. Thus, in Taiwanese men with AGA, finasteride 1 mg/ day for 1 year slowed the progression of hair loss and increased hair growth.