When a device does not meet cleanliness standards, it not only impairs its normal function but also hinders the sterilization effect. Causing sudden infections in a hospital is not difficult and affects patients' safety and the hospital's reputation. The Ministry of Health and Welfare established the "Management Mechanism for Disinfection or Sterilization of Medical Devices" to promote its patient safety implementation strategy in 2018-2019. Therefore, this article discusses the equipment management of contaminated areas and protective equipment during cleaning. The transportation methods, cleaning procedures, and monitoring of cleaning quality of dirty equipment are summarized. The purpose of this study was to improve the cleaning and decontamination of medical equipment and promote compliance with the standard operating procedures of equipment cleaning to prevent incomplete cleaning. Thus, patient and staff safety can be ensured.