An Original Discovery: Selenium Deficiency and Keshan Disease (an Endemic Heart Disease)

原始發現：硒缺乏與克山病（一種高致死率的地方性心臟病）

Jun-Shi Chen

《Asia Pacific Journal of Clinical Nutrition》 21卷3期 (2012/09) Pp. 320-326

https://doi.org/10.6133/apjcn.2012.21.3.01

摘要

本文報告50年前中國的一項硒缺乏與克山病（一種高致死率的地方性心臟病）的研究，作爲營養學轉化研究的一個實例。大量橫斷面流行病學研究表明，糧食硒含量低和人群硒營養狀況低下與克山病發病相關。數個用口服亞硒酸鈉片的大型人群干預實驗，見到克山病發病明顯下降。根據上述證據，得出硒缺乏是克山病主要病因的結論；儘管不能完全排除其他致病因素。這些研究發現有以下意義：提供了硒為人體必需微量元素的重要證據；確定硒的人體最低需要量並為RDA/RNI提供了科學依据；爲制定中國有效防治克山病的措施提供了堅實的參考信息。

關鍵字

硒 ； 克山症 ； 轉化研究 ； 必需微量營養素

並列摘要

This is a review article telling a 50-years old story about the studies on selenium deficiency and Keshan disease in China, an endemic heart disease with high case-fatality, as an example of translational research. Extensive cross-sectional epidemiological studies showed that low selenium concentrations in cereal grains and low selenium status of local residents were associated with the occurrence of Keshan disease. Several large population-based intervention trials using oral administration of sodium selenite tablets showed significant reduction of Keshan disease incidence. Based on the above evidence, it was concluded that selenium deficiency is the major cause of Keshan disease, although other etiological factors could not be ruled out. The implications of the findings include: provided critical scientific evidence for selenium being an essential trace element for humans; as scientific basis for identifying minimum requirement and RDA/RNI for selenium; and as solid reference for the formulation of effective preventive measures for Keshan disease in China.

並列關鍵字

selenium ； Keshan disease ； translational research ； essential trace element