Primary Cerebellar B cell lymphoma: A case report

Introduction: Primary central nervous system lymphoma (PCNSL) is usually a diffuse large B cell non-Hodgkin lymphoma that originates in the brain, spinal cord, leptomeninges or eyes. Primary central nervous system lymphoma is a rare malignant tumor comprising less than 3% of all primary brain tumors. The PCNSL in immunocompetent patients is most commonly supratentorial, found adjacent to the ventricular surfaces and in deep white matter and subcortical structures, such as the basal ganglia, thalamus and corpus callosum. The lesion is single in 60-70% of patients. Lesions are located in the hemispheres (38%), thalamus/basal ganglia (16%), corpus callosum (14%), periventricular region (12%) and cerebellum (9%). Herein, we report an extremely rare case of a primary CNS B cell lymphoma involving cerebellum. Case Report: A 55-year-old female was presented with vomiting, ataxia and disorientation. T2-weighted axial, T1-weighted and gadoliniumenhanced T1-weighted axial magnetic resonance imaging scans show a contrast enhancing mass with peritumoral edema in the right cerebellar hemisphere. Excision biopsy was suggestive of non-Hodgkin lymphoma. Diagnosis was confirmed with immunohistochemistry favoring non-Hodgkin lymphoma of diffuse large B cell type. This patient received cytotoxic therapy with carmustine 200 mg IV 6 weekly 3 cycles followed by external beam radiation therapy 30 Gy. No recurrence was noticed in one year follow-up. Conclusion: Primary B cell lymphoma limited to the CNS is exceedingly rare in the middle aged immunocompetent individual. Little is known regarding etiologic factors, optimal management and prognosis.

並列關鍵字

Non-Hodgkin lymphoma ； Carmustine ； B-cell lymphoma ； Cerebellum

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