Cement-retained implant prostheses have been the most popular option in prosthodontic treatment involving implants. Compared to screw-retained implant prostheses, the cement type is simpler and allows a certain tolerance for production errors. However, the marginal accuracy of full-coverage restorations may be adversely affected by the cementation technique. The aims of the present study were to investigate the effect of venting design and different cements on the retention and marginal adaptation of cement-retained implant prostheses. Twenty CeraOne (Nobel Biocare) crowns, 10 with and 10 without venting, were cemented to implant abutments with different luting agents, including zinc oxide eugenol (ZOE), glass ionomer (GI), and zinc phosphate (ZP) cements. Marginal seals and retentive strengths were respectively evaluated using a measuring microscope and a universal testing machine. Results revealed that the ZOE had the smallest marginal gap and retentive strength, and the ZP produced the highest retentive bond and largest cement gap. The venting design of the CeraOne system significantly reduced the marginal discrepancies of implant crowns cemented with the GI and ZP cements, but did not increase the retentive strength of the cements tested. Using different cements in the CeraOne system significantly influences the retentive strength and marginal gaps. These results should provide valuable information for progressive cementation of cement-retained implant prostheses.