Evaluation of Zinc Oxide Ointment by Rheological Method

氧化鋅軟膏為常用於治療皮膚病的製劑。由於該製劑塗敷於受傷的皮膚，因而為防止二度傷害，該製劑也須有適當的物化性質，均勻性佳及不具刺激性。在本研究中，使用流變學的方法，鏡檢法和氧化鋅含量分析法，評估氧化鋅軟膏於製造過程中研磨時間對製劑品質的影響。所得結果顯示以盤錘式黏度計之流變學方法可用於評估製劑的均勻性及粒子的分布情形。此法較鏡檢法、含量分析法簡便，並能得到軟膏製劑的流變曲線，因而可應用於此類製劑的品質評估。

關鍵字

氧化鋅軟膏；流變學；均勻性

並列摘要

Zinc oxide ointment is frequently used in the treatment of skin disorders. Since the preparation was applied on the damaged skin, for decreasing further to injure the skin, the zinc oxide ointment should have suitable physico-chemical properties, good homgoenicity and nonirritation. In this study, we used rheological method, optical examination and assay method to evalute the ointment.During the manufacturing process, the effect of mixing time on the particle size distribution, content uniformity and viscosity of the zinc oxide were measured. The results indicated that the cone-plate viscometer of the rheological method was capable of estimating the homogenicity and particle size distribution of the preparation. The method was easily operated which was simpler than the optical examination and the assay method. In addition, a continuous rheological curve could be obtained from the determination of viscosity which might be applied to other ointment for the evaluation of the quality of product.

並列關鍵字

Zinc Oxide Ointment ； Rheology ； Homogenicity

國際替代計量

Evaluation of Zinc Oxide Ointment by Rheological Method

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