- 期刊
Pharmacological Effects of Evodia Rutaecarpa and Its Bioactive Components
並列摘要
The chemical components and pharmacological effects of a Chinese herbal drug Wu-Chu- Yu, the dry unripe fruit of Evodia rutaecarpa (Juss.) Benth (Evodiae Fructus, E.F.), have been studied by us since 1976. Totally, thirty-eight chemicals are isolated and identified from Evodiae plants in Taiwan. Among them, eight (7-hydroxyrutaecarpine, and 7 novel aceptophenones) are characterized as new chemicals. Under bioassay directed fractionation, three compounds, dehydroevodiamine (DeHE), evodiamine (Evo) and rutaecarpine (Rut) are isolated and studied pharmacologically. Further studies demonstrate that DeHE produces a hypotensive and bradycardic effecds in SHR, but not in WKY rats. However, higher doses of Rut (2.5-20 mg/kg, i.p.) increase blood pressure in conscious WKY rats but not in SHR. Evo also produces hypotensive and tachycardiac effects in conscious SHR but not in WKY rats. Endothelium activation and receptor-mediated Ca2+ channels inhibition in the vascular smooth muscle are involved in the vasorelaxant effect of DeHE, Evo and Rut. The vasorelaxant effect of Rut is 100% endothelium dependent in the aorta but only 65-70% in mesenteric artery. Evo exerts 50% endothelium dependence in aorta and 20% in mesenteric artery. Vasorelaxant effect of DeUE in mesenteric artery is 20% endotheliumdependent, but not endothelium dependent in the aorta. Recently, the anti-amnesia effect of DeHE in intracerebroventricular β-amyloid peptide injected mice is shown. Studies also show the effect of E.F. and its bioactive components on septic-shock rats, on rabbit corpus cavernosum, and on testosterone and aldosterone secretion in rat testicular interstitial cells and Zona glomerulosa cells. The interaction of E.F. and its bioactive components between various drugs metabolizing enzymes is further demonstrated.
延伸閱讀
- 陳冠宏（2021）。Assessment of the efficacy of Corbicula fluminea and Momordica charantia complex on blood lipid regulation〔碩士論文，國立屏東科技大學〕。華藝線上圖書館。https://doi.org/10.6346/NPUST202100333
- Shen, X., Zhao, Z., Wang, H., Guo, Z., Hu, B., & Zhang, G. (2017). Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses. Mediators of Inflammation, 2017(), 1-10. https://doi.org/10.1155/2017/3709874
- 吳泰賢、項千芸、侯庭鏞、林松水、李意旻（2009）。Extract from the Fruit of Evodia Rutaecarpa and Its Role in the Reduction of AP-1 Activity and Cell Transformation in Cancer Cell Lines。Journal of Biomedical & Laboratory Sciences，21(1)，14-22。https://doi.org/10.30046/JBLS.200905.0003
- Janardhan, A., Kumar, A. P., Viswanath, B., Saigopal, D. V. R., & Narasimha, G. (2014). Production of Bioactive Compounds by Actinomycetes and Their Antioxidant Properties. Biotechnology Research International, (2014), 22-29. https://doi.org/10.1155/2014/217030
- 王隆碩、徐泓群、藍誼珊、蕭銘輝、陳豪君、李俊廷、王淑綺（2015）。Literature Review of Pharmacological Effects and Toxicity of Divaricate Typhonium。中醫藥研究論叢，18(2)，32-41。https://doi.org/10.6516/TJTCM.2015.18(2)32