Effect of Capsaicin on Detrusor Contractility-A Preliminary Study in Human and Rat Urinary Bladders

紅辣椒素對逼尿肌收縮力之作用─人類及大白鼠膀胱之初步研究

郭漢崇(Hann-Chorng Kuo)

《慈濟醫學雜誌》 7卷3期 (1995/09) Pp. 167-178

https://doi.org/10.6440/TZUCMJ.199509.0167

摘要

為了瞭解了辣椒素敏感之感覺神經在逼尿肌收縮力扮演之角色，我們在大白鼠活體進行膀胱收灌注，並利用大白鼠離體膀胱進行離體實驗，同時也進行離體膀胱肌肉之收縮力研究（人及大白鼠）。在活體之大白鼠膀胱灌注低濃度之紅辣椒素顯示會有興奮作用，但在高濃度之下則在興奮作用之後出現抑制逼尿肌收縮的現象。在表面灌注紅辣椒素之膀胱的離體全膀胱實驗中，以及離體之肌賽實驗中，顯示只有在1 mM紅辣椒素濃度下，才能達到明顯抑制逼尿肌收縮力的效果（電激及bethanechol刺激）。在人類的膀胱肌肉條實驗中，紅辣椒素可引發微弱的收縮，而且與劑量相關。但也要達到1mM才能達到抑制逼尿肌收縮的效果。這個初步研究結果顯示，紅辣椒素可以使感覺神經末稍釋放出一些神經多胜肽可能會減低逼尿有影響。缺乏這些神經多胜肽可能會減低逼尿肌之收縮力，甚至抑制反射性排尿，但是一定要在高濃度之下這個效果才能達到。

關鍵字

紅辣椒素 ； 膀胱功能 ； 排尿反射

並列摘要

In order to understand how capsaicin affects detrusor contractility in rat and human urinary bladders, studies were undertaken. In the first study, capsaicin was administered intravesically to in vivo rats ; in the second, capsaicin was administered to in vitro rat bladdes; and in the third, capsaicin was administered to in vitro human bladders. Intravesical administration of low concentrations of capsaicin exerted an excitatory eddect on detrusor contractility in in vivo art urinary bladders, whereas intravesical administration of high concentrations of capsaicin had an inhibitory effect. In the isolatedwhole rat bladder study and in the in vitro rat bladder muscle strip study, a high concentration of at least imM was necessary for achieving an inhibitory effect under dither electrical or bethanechol stimulation. In the human bladder muscle strip study, the effect of capsaicin was more evident and dose-dependent. The results of these studies show that capsaicin releases neuropeptides in both rat and human bladders. It has been hypothesized that the release of these neuropeptides might facilitate normal detrusor contractility as well as reflexic micturition whereas a lack of these neuropeptides might inhibit normal detrusor contractility and reflexic micturition. A high concentration of capsaicin (more than 1 mM) was necessary in order to achieve this effect in both rat and human bldders.

並列關鍵字

capsaicin bladder function ； micturition reflex