The etiology of multiple bone pain is numerous, while the possibility of parathyroid adenoma is often overlooked. This article reports a 23-year-old female patient with multiple bone pain. Bone scan showed typical metabolic bonedisease. The 201TI/(superscript 99m)Tc subtraction and (superscript 99m)Tc sestamibi parathyroid imaging further localized a right upper parathyroid adenoma and led to a successful operative intervention.