We reported the case of a 22-year-old female presenting with disseminated and complicated tuberculosis (TB) infection with multiple endocrine disturbances. The patient had miliary pulmonary TB, TB meningitis with tuberculoma, and tuberculous enteritis. She also had multiple endocrine disturbances, including hypothyroidism, hypogonadism, and growth hormone deficiency. After 5 months of thyroxin supplement, all the endocrine disturbances, especially of the thyroid, had returned to normal under effective anti-tuberculous drug treatment. To now the best of our knowledge, there has been no published report such as ours of a case of disseminated and complicated TB with endocrine disturbances.