藥物引起牙齦腫大之探討及治療

A Review and Treatment in Drug Induced Gingival Overgrowth

劉弘凱(Hung-Kai Liu) ； 邱賢忠(Hsien-Chung Chiu) ； 傅鍔(Fu Earl) ； 江正陽(Cheng-Yang Chiang)

《臺灣牙周病醫學會雜誌》 13卷3期 (2008/09) Pp. 217-230

https://doi.org/10.6121/TAP.200809_13(3).0003

摘要

藥物引起的牙齦腫大常發生在前牙區。除了造成美觀不佳以外，也影響發音、咀嚼、及口腔清潔的保持。本文針對藥物引起牙齦腫大的臨床表徵、組識特徵、危險因子、病理機轉、以及治療方式做一文獻回顧，並提出三個分別服用鈣離子阻斷劑、兔疫抑制劑、抗癲癇藥物的臨床病例。經由仔細的口腔衛教及牙菌斑控制，大約兩個月後，患者牙齦的發炎外觀得到大幅軟組識癒合，甚至在第一、二病例中前牙齒間縫隙也有自動閉合的現象。文中還整理出常引起牙齦腫大的藥物中英文商品名對照表，以作爲牙醫師臨床參考。

關鍵字

牙齦腫大 ； 鈣離子阻斷劑 ； 免疫抑制劑 ； 抗癲癇藥物

並列摘要

Drug-induced gingival enlargement occurs frequently in the anterior segment of gingival tissue. Except for aesthetic disfigurement, gingival enlargement could also affect pronunciation, mastication, and oral hygiene. This article highlighted the review of clinical manifestations, histological characteristics, risk factors, pathogenesis and management of the drug-induced gingival enlargement. In addition, we also presented three clinical cases associated with calcium channel blockers, immunosuppressants and antiepileptic drugs. The patients were instructed with Bass method for oral hygiene and treated with scaling/ root planing for plaque control carefully. Around two months later, the gingival inflammed appearance obtained great soft tissue healing, and even the inter-incisor space could have auto-correction at first two cases. Furthermore, we listed Chinese and English commercial name of the drugs, which frequently induce gingival enlargement, as a reference for dentists.

並列關鍵字

gingival overgrowth ； calcium channel blockers ； immunosuppressants ； antiepileptic drugs