Blood Group Non-O May Be Associated with an Increased Risk of Venous Thrombosis: Taiwan Thrombophilia Study

非O型者較易發生深部靜脈栓塞：台灣深部靜脈栓塞好發症研究

林正修(Jen-Shiou Lin) ； 沈銘鏡(Ming-Ching Shen) ； 洪惠青(Huey-Ching Horng) ； 范杏淳(Hsing-Chun Fan) ； 游雅言(Ya-Yan Yu) ； 洪美華(Mei-Hua Hung) ； 林賓賓(Bin-Bin Lin) ； 王瑛琦(Ying-Chi Wang)

《The Changhua Journal of Medicine》 7卷3期 (2002/07) Pp. 141-146

摘要

背景及目的：西方人ABO血型和血管栓塞有密切關係，但類似的研究在華人則少見。本研究的目的即在探討台灣人ABO血型和深部靜脈栓塞之相關性。
方法：收錄深部靜脈栓塞病人為研究個案，而且去除栓塞的原因與癌症、骨髓增生症、肝疾、腎疾、手術或懷孕有關的個案；隨意收錄符合病人性別及年齡且無血管栓塞病史之健康者為對照組。配對好之個案採血球凝集法測試ABO血型。採用邏輯回歸分析血型是否是為深部靜脈栓塞之危險因子。
結果：本研究共有94位病人及94位健康者配對。兩組年齡並無顯著差異(P=0.895)。病人血型之頻率為A型29.8%、B型34.0%、AB型11.7%及O型24.5%；對照組為A型31.9%、B型21.3%、AB型7.4%及O型39.4%。病人之非O型頻率比對照組顯著為高(P=0.031)。回歸分析顯示非O型比O型有兩倍罹患深部靜脈栓塞之機會（危險比值，2.03；95%信賴區間，1.08-3.82）。非O型中，B型相對於O型有最高之罹病機會（危險比值，2.64；95%信賴區間，1.22-5.74）。
結論：ABO血型和台灣人深部靜脈栓塞好發症之發生有顯著相關，其中非O型可能是深部靜脈栓塞發生之危險因子。

關鍵字

靜脈栓塞 ； 深部靜脈栓塞好發症 ； 血型 ； 危險因子 ； 台灣人

並列摘要

Background and purpose: Many studies on Caucasians have reported a relationship between ABO blood group and vascular thrombosis. Such findings are rarely reported in Taiwan inhabitants. The aim of this study was to investigate the association of the ABO blood group with venous thrombosis in the Taiwan population.
Methods: Consecutive patients with venous thrombosis unrelated to malignancy, myeloproliferative disorder, liver disease, renal disease, surgery and pregnancy were recruited. Apparently healthy subjects without any history of vascular thrombosis were selected at random and matched to the patients for sex and age. The ABO blood group was determined in all subjects using an isoagglutination method. Logistic regression was used to assess the risk of thrombosis and to calculate the odds ratio (OR) with a 95% confidence interval (CI).
Results: A total of 94 patients and 94 controls were investigated. The age distribution was not different between these two groups (P=0.895). The frequencies of blood groups A, B, AB and O were 29.8%, 34.0%, 11.7% and 24.5%, respectively, among patients, whereas they were 31.9%, 21.3%, 7.4% and 39.4%, respectively, among controls. The frequency of blood group non-O was higher in the patient group than that in the control group (P=0.031). Blood group non-O was associated with a two-fold increased risk of venous thrombosis when compared with blood group O (OR, 2.03; 95% CI, 1.08-3.82). Of blood group non-O, blood group B was associated with the highest risk of venous thrombosis (OR, 2.64; 95% CI, 1.22-5.74).
Conclusion: ABO blood group is associated with venous thrombosis. Blood group non-O may be a potential and common risk factor for venous thrombosis in Taiwan.

並列關鍵字

venous thrombosis ； venous thrombophilia ； blood group ； risk factor ； Taiwan population