硫胺素缺乏：流行病學、病理生理學、臨床特徵，及實驗室檢查

Thiamin Deficiency: Epidemiology, Pathophysiology, Clinical Characteristics, and Laboratory Test

陳國東(Kow-Tong Chen) ； 蘇世斌(Shih-Bin Su)

《台灣家庭醫學雜誌》 26卷1期 (2016/03) Pp. 1-10

https://doi.org/10.3966/168232812016032601001

摘要

硫胺素缺乏症會導致腳氣病及多重器官衰竭。在工業化社會中硫胺素缺乏的罹病率低，但在開發中國家（尤其亞洲）仍是重要的健康議題。本研究的目的是探討硫胺素缺乏的流行病學、病理生理學、臨床特徵及實驗室檢驗。以關鍵字“硫胺素”或“硫胺素缺乏”在PubMed學術網站上搜尋相關發表的文獻。硫胺素缺乏的診斷除了根據臨床症狀及實驗室檢驗外，給與硫胺素治療症狀可戲劇性的緩解，但若給予利尿劑治療，相關症狀若是更加嚴重可作為間接證據。對營養不良、心臟衰竭、糖尿病、長期靜脈灌注或減重的高危險群，需確認他們有足夠的維生素補充。

關鍵字

硫胺素 ； 硫胺素缺乏 ； 維生素B_1 ； 腳氣病

並列摘要

Thiamin deficiency (TD) can lead to beriberi and multi-organ failure. Despite its low prevalence in the industrialized world, TD remains a major health problem in developing countries, esepcially those in Asia. The purpose of this review was to examine the epidemiology, pathophysiology, clinical characteristics, and laboratory test of thiamin deficiency. Related literature was identified using keywords ＂thiamin＂ or ＂thiamin deficiency＂ to search PubMed. The diagnosis of TD is based on clinical symptoms and and laboratory test results. Thiamin infusion alleviates symptoms effectively only for patients with thiamin deficiency. It is also noted that symptoms of TD might be aggravates when diuretic was used. Patients with poor nutritions, heart failure, diabetes, long-term parenteral infusion or surgical intervention for obesity are at high risk of thiamine deficiency. Adequate nutritional supplement for them should be ensure.

並列關鍵字

beriberi ； thiamin ； thiamin deficiency ； vitamin B_1

參考文獻

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