馬藍化學成分之研究

A Study of the Constituents of Strobilanthes Cusia (NEES) KUNTZE

陳建志(Chien-Chih Chen) ； 劉倩君(Chian-Jiun Liou) ； 黃文盈(Wen-Ying Huang) ； 林傳福(Chwan-Fwu Lin) ； 詹雅玲(Ya-Ling Chan) ； 顏雅玟(Ya-Wen Yen)

《長庚科技學刊》 13期 (2010/12) Pp. 149-155

https://doi.org/10.6192/CGUST.2010.12.13.12

摘要

馬藍(Strobilanthes cusia (Nees) O. Kuntze)爲爵床科(Acanthaceae)植物，其根和莖習稱爲“南板藍根”，味苦性寒，具有清熱解毒，涼血消腫之功效，爲板藍根的基原植物之一。
馬藍之商品品質不一，共有六種，本實驗就臺灣產馬藍Strobilanthes cusia進行一系列之層析分離及純化共得到10個化合物，經光譜分析及化學方法並參考文獻資料確認結構爲2-hydroxyquinazolin-4(1H)-one (1)、2,4(1H,3H)-quinazolinedione (2)、4-methoxy-2(1H)-quinazolineone (3)、2-hydroxy-1,4-benzoxazin-3-one (4)、2-benzoxazolinone (5)、indirubin (6)、tryptanthrin (7)、lupeol (8)、betulin (9)和1-hydroxy-3-methyl-9,10-anthraquinone (10)。其中1、3和10三個化合物爲首次自本植物分離之化合物。

關鍵字

層析分離 ； 馬藍 ； 板藍根

並列摘要

The root of Strobilanthes cusia, popularly known as ”Ban-Lan-Gan” is a herb commonly used in Chinese medicine for antipyretic, antiviral, and detoxifying purpose. Chromatographic separation of a methanol extract of Strobilanthes cusia resulted in the isolation of ten compounds. Based on the spectroscopic data and chemical analysis, the compounds were determined to be:
(1.) 2-hydroxyquinazolin-4(1H)-one
(2.) 2,4(1H,3H)-quinazolinedione
(3.) 4-methoxy-2(1H)-quinazolineone
(4.) 2-hydroxy-1,4-benzoxazin-3-one
(5.) 2-benzoxazolinone
(6.) indirubin
(7.) tryptanthrin
(8.) lupeol
(9.) betulin
(10.) 1-hydroxy-3-methyl-9,10-anthraquinone
Among these, compounds 1, 3 and 10 were isolated for the first time from this plant.

並列關鍵字

Chromatographic separation ； Ban-Lan-Gan