Performance of a CO boiler has a detrimental influence on the operation and production of related industries. In a previous study, the author has presented a numerical study of the influence of insulation thickening on the heat transfer and fluid flow in a CO boiler. In the present paper, the influence of insulation thickening on the reacting flow in a CO boiler is discussed. It is found that insulation thickening can alleviate the adverse pressure gradient in the DeNOx section and therefore strengthen the convective motion in the core region. This will decrease the higher temperature range and the shear strain rate in the upper portions of the DeNOx and flue gas cooling sections. On the other hand, the oxidation section which is located in the upstream region of a CO boiler is less influenced by the insulation thickening effect.