- 期刊
- OpenAccess
Hepatoprotective Activity of Aqueous Acetone Extract from ＂Cienfuegosia digitata＂ Cav. (Malvaceae) Against Alcohol Hepatotoxicity in Albinos Wistar Rats
並列摘要
The present study was conducted to evaluate the hepatoprotective effects of aqueous acetone extract of ＂Cienfuegosia digitata＂ Cav. (Malvaceae) an herbal plant used in Burkina Faso to treat traditionally liver disease in albinos Wistar rats. Animals received by gavage 25, 50 and 100 mg/kg body weight of extract daily for a period of 28 days. Control groups received alcohol 35% and water. In vivo administration of 35% ethanol for a period of 28 days in rats showed an activity of liver marker enzymes (AST, ALT, ALP and GGT), triglycerides, total cholesterol, total bilirubin and direct bilirubin in serum compared with rats which received water (control water). However, administration of 35% ethanol along with aqueous acetone extract decreased the activities of liver markers enzyme in serum comparatively to the control water group (p＜0.05 or p＜0.01). We noticed that extract at a dose of 100 mg/kg body weight was highly effective than 25 and 50 mg/kg body weight compared to the control water group (ALT and ALP; p＞0.05 and p＜0.05). This study revealed that ＂Cienfuegosia digitata＂ presents a hepatoprotective potential and this plant could be traditionally exploited in the treatment of liver disease particularly hepatitis B in Burkina Faso.
延伸閱讀
- Konaté, K., Souza, A., Samseny, R. R. R. A., Batchelili, B., Marlaine, B., Lamidi, M., Barro, N., Rasolodimby, J. M., & Nacoulma, O. G. (2011). Hepatoprotective Effect of Aqueous Acetone Extract of Sida alba L. (Malvaceae) Against Alcohol Induced Liver Damage in albinos Wistar Rats. British Journal of Pharmacology and Toxicology, 2(1), 37-42. https://www.airitilibrary.com/Article/Detail?DocID=20442467-201102-201507070011-201507070011-37-42
- Uduak., E. U., Timbuak, J., Musa, S., Ikyembe, D., Abdurrashid, S., & Hamman, W. (2012). Ulceroprotective Effect of Methanol Extract of Psidium guajava Leaves on Ethanol Induced Gastric Ulcer in Adult Wistar Rats. Asian Journal of Medical Sciences, 4(2), 75-78. https://www.airitilibrary.com/Article/Detail?DocID=20408773-201204-201510290013-201510290013-75-78
- Gwarzo, M. Y., & Muhammad, U. (2014). Evaluation of Hypoglycaemic Effect and Antioxidant Property of Entada Abyssinica Leaves Powder on Alloxan Induced Diabetic Mice. International Journal of Animal and Veterinary Advances, 6(5), 135-138. https://www.airitilibrary.com/Article/Detail?DocID=20412908-201410-201507200030-201507200030-135-138
- Alam, J., Mujahid, M., Badruddeen, Jahan, Y., Bagga, P., & Rahman, M. A. (2017). Hepatoprotective potential of ethanolic extract of Aquilaria agallocha leaves against paracetamol induced hepatotoxicity in SD rats. Journal of Traditional and Complementary Medicine, 7(1), 9-13. https://doi.org/10.1016/j.jtcme.2015.12.006
- 林信伶（2004）。Hepatoprotective, Antiviral and Anticancer Effects of Toona sinensis Roem. and its regulation on intracellular NO/cGMP level.〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2903200614010802