A Study of the Anti-Inflammator Y and Analgesic Activities of Aqueous Extract of Nauclea latifolia Leaves in Rodents

A.D.T. Goji ； A. Mohammed ； Y. Tanko ； I. Ezekiel ； A.O. Okpanchi ； A.U.U. Dikko

《Asian Journal of Medical Sciences》 2卷6期 (2010/12) Pp. 244-247

並列摘要

This study investigates the anti- inflammatory and analgesic activity of the leaves extract of Nauclea latifolia in formalin induced oedema and acetic acid induced writhing in Rodents. The aqueous extract of the leaves of Nauclea latifolia of the family of Rubiaceae w as evaluated for its analgesic and anti-inflammatory activities. The extract exhibited significant p＜0.05 and dose dependent analgesic activities between 50,100 and 150mg/kg body weight i.p. in acetic acid induced writhing and anti-inflammatory effects between 50 and 100mg/kg body weight i.p. in formalin induced oedema in rats. The activities of the extract were comparable to that of the reference non- steroidal analgesic and anti-inflammatory drug: piroxicam. LD_50 value was calculated to be 226.3mg/kg body weight intraperitoneally. The extract revealed the presence of chemical constituents such as flavonoid, tannins alkaloid and saponins when phytochemically investigated. The results obtained from the present studies supported the claims of the use of the plant in the management of dysentery and pain in the throat in human.

並列關鍵字

Acetic acid ； analgesic ； anti-inflammation ； formalin ； Nauclea latifolia ； piroxicam