- 期刊
- OpenAccess
Uric Acid and Atrial Fibrillation: A systematic review and meta-analysis
尿酸與心房顫動：系統回顧與統合分析
摘要
Background : Hyperuricemia is undoubtedly associated with the development of cardiovascular disease (CVD). Herein, we describe the results of a systematic review and meta-analysis of observational studies conducted to explore the relationship between serum uric acid (sUA) and atrial fibrillation (AF). Methods : PubMed, Cochrane, and Web of Science databases were comprehensively and electronically searched using EndNote X9 for articles published up to March 31, 2019. The search terms used were ＂uric acid,＂ ＂urate,＂ ＂hyperuricemia,＂ or ＂gout＂ AND ＂atrial fibrillation.＂ This method was repeated with the Chinese Electronic Periodicals Service (CEPS) in Taiwan. Review Manager (ver. 5.3) was used to derive standardized mean differences (SMDs) with 95% CI (confidence intervals), heterogeneity (I^2), weights, and Funnel plots. Forest plots were drawn using MS-Excel and VBA wherein significant difference is indicated by error bars that do not cross the no effect line at X = 0.0. Results : A total of 29 studies with 372,638 patients were included for quantitative analyses differences in sUA levels between the patients with and without AF. The sUA level in patients with AF was found to be significantly higher than those without AF (SMD 0.63; 95% CI 0.49-0.78; P ＜ 0.00001). Conclusions : As sUA levels are significantly higher in AF patients, it may be used as a potential biomarker of AF risk.
並列摘要
背景：高尿酸血症與心血管疾病（CVD）有關，在此，我們以系統回顧和統合分析觀察性的研究，以探討血清尿酸（sUA）與心房顫動（AF）間的關係。方法：以PubMed，Cochrane和Web of Science搜索2019年3月31日前的文章，使用以下搜索策略：（“uric acid＂或“urate＂或“hyperuricemia＂或“gout＂）且“atrial fibrillation＂，同時使用相同的中文關鍵詞搜索台灣CEPS（Chinese Electronic Periodicals Service）。以Review Manager 5.3計算標準化平均差異（SMD）、95%CI、異質性（heterogeneity, I^2）、權重及漏斗圖。結果再使用MS-Excel和VBA繪製森林圖，如果誤差線沒有交叉到無效線X = 0.0，則表示達統計學上顯著的差異。結果：共納入29項研究之372,638名患者，結果發現AF患者的sUA顯著高於無AF患者（SMD 0.63;95%CI 0.49-0.78; P ＜0.00001）。結論：研究發現AF患者的sUA水平顯著升高，因此，它可能是AF風險的潛在生物標誌。