The Anti-Hepatitis Effect by Tao-He-Cheng-Qi-Tang on Acetaminophen (APAP) Induced Rats

Tung-Yuan Lai ； Yi-Jiun Weng ； Wei-Kung Chen ； Yueh-Min Lin ； Fuu-Jen Tsai ； Yi-Chang Cheng ； Li-Mien Chen ； Eric Y. C. Lai ； Chih-Yang Huang ； Jin-Ming Hwang

《Adaptive Medicine》 3卷1期 (2011/04) Pp. 16-20

https://doi.org/10.4247/AM.2011.ABA006

並列摘要

Tao-He-Cheng-Qi-Tang (THCQT) for medical purposes has been known for centuries. It has been recognized to as a means to treat diabetes mellitus, amenorrhea, chronic hepatitis, and chronic pyelonephritis. In order to test for THCQT's ability to scavenge free radicals, we examined the ability of THCQT to react with hydroxyl radical to investigate the effect of THCQT on acetaminophen (APAP)-induced hepatitis. Male Wistar rats were administered with 0.3 or 0.5 g/kg of THCQT, and silymarin (25 mg/kg) as the positive control group. All testing substances were orally administered 1 h before the intraperitoneal injection of APAP (500 mg/kg). After 24 h of APAP injection, the rats were sacrificed to observe their liver histopathology, and evaluated for their glutamate oxalate transaminase (GOT), glutamate pyruvate transaminase (GPT), and lipid peroxidation (LPO) level. THCQT significantly inhibited LPO level induced by Fe^(3+)/ascorbic acid in vitro. THCQT protected the liver from APAP-induced injuries by preventing the increase of liver function markers, GOT and GPT. THCQT even showed more significantly effects than the silymarin. Although THCQT did not significantly change the increase of hepatic LPO induced by APAP, THCQT did increase hepatic glutathione (GSH) more significantly than the APAP group and the silymarin group. We concluded that the antioxidant abilities and anti-hepatitis effect of THCQT may be potentially useful in counteracting free radical-mediated diseases.

並列關鍵字

Chinese traditional medicine ； acetaminophen