Stem cell therapy for early stage osteonecrosis: challenges and future research directions

Over the past decade, several clinician researchers have started to evaluate the role of Mesenchymal stem cells (MSCs) in treatment of osteonecrosis (ON). Gangji et al. and Hernigou et al. have successfully used autologous bone marrow concentrate for treatment of early stage ON. Both investigators have reported midto long-term favorable results. However, contradictory results were also reported using similar techniques and patient populations. In addition, many questions are yet unanswered and only limited information is available in the literature in terms of clinical trials and surgical techniques in humans using MSCs as adjunct therapies. This manuscript will review literatures related to MSCutilizing surgical techniques and explore some of the limitations and future research directions of using stem cell therapies in osteonecrosis.

並列關鍵字

cell therapy ； core decompression ； femoral head ； mesenchymal stem cell ； osteonecrosis

被引用紀錄

王全毅（2008）。中共對台政策之研究(2002~2006)〔碩士論文，淡江大學〕。華藝線上圖書館。https://doi.org/10.6846/TKU.2008.00621

余政毅（2003）。交通安全宣導工作執行績效之調查與檢討〔碩士論文，元智大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0009-0112200611313514

延伸閱讀

Khan, W. S., Longo, U. G., Adesida, A., & Denaro, V. (2012). Stem Cell and Tissue Engineering Applications in Orthopaedics and Musculoskeletal Medicine. Stem Cells International, 2012(), 387-388. https://doi.org/10.1155/2012/403170
Baugé, C., & Boumédiene, K. (2015). Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments. Stem Cells International, 2015(), 785-798-070. https://doi.org/10.1155/2015/438026
Kristjánsson, B., & Honsawek, S. (2014). Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis. Stem Cells International, (2014), 47-59. https://doi.org/10.1155/2014/194318
Hernigou, P., Lachaniette, C. H. F., Bouthors, C., Roubineau, F., Chevallier, N., & Rouard, H. (2016). Osteonecrosis repair with stem cells: 30 years of experience from bone marrow concentration to cultured mesenchymal stem cells. Formosan Journal of Musculoskeletal Disorders, 7(3), 127-137. https://doi.org/10.6492/FJMD.20160126
Hernigou, P., Lachaniette, C. H. F., Bouthors, C., Roubineau, F., Chevallier, N., & Rouard, H. (2015). Osteonecrosis repair with stem cells: 30 years of experience from bone marrow concentration to cultured mesenchymal stem cells. Formosan Journal of Musculoskeletal Disorders, (), c1-11. https://doi.org/10.6492/FJMD.20160126

國際替代計量

Stem cell therapy for early stage osteonecrosis: challenges and future research directions

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