Aims: This article is a case series with respect to the four year experience of Whipple's procedure at Government Medical College and Hospital Nagpur. In this study, we have studied the demographic details of the patients, various indications for Whipple's procedure, the cofactors which affect the procedure its outcome and causes of morbidity and mortality among operated patients. Methods: This study was performed by collecting data about patients undergoing Whipple's procedure from operation theatres and medical record section. Those patients, whose tumor was unresectable and undergone palliative surgical procedures were excluded from the study. Results: From May 2011 till May 2015, 51 cases were collected and analyzed. Adenocarcinoma pancreas was the most common indication for the procedure. 18 out of 33 patients presented with jaundice had undergone preoperative biliary stenting. Mean operation time was less in patients in whom ultrasonic scalpel was used and who had not undergone preoperative stenting. The most prevalent cause of reoperation was hemorrhage. Major postoperative morbidity of these patients was due to pneumonia (23.4%). Minor postoperative complications were wound infection and delayed gastric emptying. Conclusion: In this study, we have concluded that usage of ultrasonic scalpel, avoidance of preoperative stenting experience of surgeon and supporting staff has led to decrease in operative duration and blood loss. Pulmonary complications and septicemia secondary to anastomotic leakage are the most common causes of morbidity and mortality.