- 期刊
實施RU486藥物流產之案例討論－以某地區教學醫院為例
Case Study of Using Mifepristone (RU486) for Early Medical Abortion
摘要
過去傳統人工流產(artificial abortion)大都使用子宮內膜搔刮術(D&C)或真空吸引術之方式，但其可能引發麻醉意外、感染、術後子宮穿孔、子宮腔粘連等危險後遺症；衛生署於2000年核准mifepristone（美服培酮，RU486）為四級管制藥品上市後，使用藥物投予的方式來終止懷孕無疑是醫學上的一大進步，因非侵襲性(non-invasive)及較輕微之副作用與併發症，提供婦女另一種安全的人工流產。 本研究以服用美服培酮(RU486)終止妊娠之婦女為主要分析對象，自2002年8月到2006年12月共146案例，分析其年齡、婚姻狀況、經產與否等因素，及有無副作用等結果，以作為服用Mifepristone(美服培酮，RU486)人工流產案例分析報告。 本研究中有18例服用美服培酮(RU486)未達預期性效果而接受子宮刮搔術，其中有16 例為不完全流產，比例為10.95%，有2件發現服用藥物後子宮內妊娠囊還存在；此外，有1例服用美服培酮(RU486)流產之個案，服用後1-2週未回診而持續懷孕至13週，發現後已無回診，無法再續追蹤。
並列摘要
Existing abortion methods such as vacuum aspiration, dilation and curettage (D & C) are not without its dangers and side effects. In the year 2000, mifepristone (RU 486) is released onto the market as a Class IV pharmaceutical under the Taiwanese Department of Health's Schedule of Controlled drugs. It is undoubtedly a major advance in medicine, as for the first time it offers safe and non-invasive means of termination of pregnancy with relatively lower complications and side effects. In this study we followed up on 146 case who had undertaken mifepristone for the termination of pregnancy from August 2002 to December 2006. We had taken into account the participants' age, marital status, parity, and any complications related to the use of mifepristone. In our study, 18 cases failed to reach the desired effect and subsequently underwent D & C. Among them, 16 cases (10.95%) had incomplete abortion and two was found gestational sac in situ. Another case had continuous pregnancy upto 13 weeks because of lost of follow up within 1 to 2 weeks after mifepristone.