- 期刊
- OpenAccess
High-Intensity Focused Ultrasound (HIFU) Ablation for Uterine Fibroids: Usefulness of 3T Diffusion-Weighted Magnetic Resonance Imaging in Pre-Treatment Evaluation of Funaki Types
摘要
PURPOSE. To assess the values of diffusion-weighted (DW) magnetic resonance (MR) imaging in pre-treatment evaluating Funaki types of uterine fibroids for high-intensity focused ultrasound (HIFU) ablation. MATERIALS AND METHODS. We retrospectively analyzed volumetric apparent diffusion coefficient (ADC) values of 80 uterine fibroids from 34 symptomatic women undergoing ultrasound-guided HIFU ablation. DW MR images (b = 0, 1000 s/ mm^2) were obtained on a 3T MR unit. Funaki type was determined based on T2-weighted MR images. Fibroids with non-perfusion volume (NPV) ratio ＞ 90% on post-HIFU MR images were defined as responders. RESULTS. Pre-treatment ADC values were significantly different among Funaki type 1, 2 and Funaki type 3 fibroids (mean ± standard deviation, 1.12 ± 0.10 vs. 1.20 ± 0.15 vs. 1.38 ± 0.21 × 10^(-3) mm^2/s, p = 0.002). The cut-off value for distinguishing Funaki type 3 from type 1/2 fibroids was determined to be 1.38 × 10^(-3) mm^2/sec, with a sensitivity of 60% and a specificity of 89%, and areas under the receiver operating characteristic curve (AUC) of 0.72 based on receiver operating characteristic (ROC) analysis. Post-treatment volumetric ADC value was significantly higher in responders than non-responders (1.36 ± 0.14 vs. 1.28 ± 0.16 × 10^(-3) mm^2/s, p = 0.018). CONCLUSION. DW MR imaging with ADC values has potentials in quantitative evaluation of Funaki types for patients with uterine fibroids before HIFU treatment.