- 期刊
猴頭菇粉結合乳酸菌複方具有降低胃內幽門螺桿菌活性的功能
Anti-Helicobacter pylori Activity by Taking Hericium erinaceus Lactic Acid Bacteria Complex
摘要
幽門螺桿菌(Helicobacter pylori)已被認為與胃炎、胃潰瘍、十二指腸潰瘍等疾病的產生有關，因此根除幽門螺桿菌感染已成為這些疾病療程的一環。然而現今第一線使用的藥物，對幽門螺桿菌的根除率正逐漸下降，因此醫界積極地尋求其它的改善療法。近年來乳酸菌與中草藥結合的產品對降低幽門螺桿菌活性或輔助疾病的治療效果漸受各界的重視，本研究為首先以藥用菇類（猴頭菇）結合乳酸菌的複方產品，觀察自願者口服複方產品後，對體內幽門螺桿菌影響的臨床試驗。結果顯示，服用猴頭菇與乳酸菌的複方產品確實能顯著降低受試者的UBT (urea breath test)值，並且在試驗期間及終止服用後2週內，無不良反應或其它健康問題產生。綜合上述，吾等認為猴頭菇與乳酸菌的複方具有降低幽門螺桿菌數量以及輔助治療胃部疾病的功能。因此，將具有開發成為保健食品的濳力。
並列摘要
Helicobacter pylori is a common gastric pathogen that causes gastritis and peptic ulcers. It is also linked to the development of duodenal ulcers. If people get an illness caused by H. pylori, they’ll need treatment to kill the germs. In recent years, the efficacy of first-line H. pylori-eradication therapy has reduced. Therefore, it is important to seek an optimal eradication therapy for H. pylori infection. The use of lactic acid bacteria and traditional Chinese medicines for the treatment of H. pylori is an active research field. This is a first-in-human study that investigates the effects of oral administration of Hericium erinaceus lactic acid bacteria complex on H. pylori infection. Results showed that UBT (urea breath test) was significantly lower after taking H. erinaceus lactic acid bacteria complex. No adverse events were noted at follow-up 2 weeks after treatment had ended. According to these results, H. erinaceus lactic acid bacteria complex has potential for use in functional foods or alternative therapy to reduce the quantity of H. pylori.