Pain on Injection of Propofol

預防Propofol注射疼痛之評估

林世祥(Shih-Shyang Lin) ； 陳冠廷(Guan-Tyng Chen) ； 林燦生(Johnson C. S. Lin) ； 陳宗鷹(Tsung-Ying Chen) ； 黃明和(Min-Huo Hwang)

《Acta Anaesthesiologica Sinica》 32卷2期 (1994/06) Pp. 73-76

摘要

A controlled randomized double-blinded clinical study was undertaken to evaluate and compare the efficacy of three methods of preventing pain during injection of propofol on induction of anesthesia. Patients were randomly allocated to six groups: saline pretreatment, followed by induction with propofol at room temperature plus saline; lidocaine pretreatment, followed by induction with propofol at room temperature plus saline; saline pretreatment, followed by induction with propofol at a temperature of 4°C plus saline; lidocaine pretreatment, followed by induction with propofol at a temperature of 4°C plus saline; saline pretreatment, followed by induction with propofol at room temperature plus lidocaine 40 mg; saline pretreatment, followed by induction with propofol at a temperature of 4°C plus lidocaine 40 mg. Pretreatment with lidocaine reduced the incidence of pain and discomfort significantly compared with unpretreated groups. Groups which received propofol mixed with lidocaine also showed a significant reduced incidence of pain. induction with cold 4°C propofol showed no significant difference in reduction of injection pain.

關鍵字

Anesthetics, intravenous: propofoI ； Anesthetics, local: lidocaine ； Complication: pain

並列摘要

Propofol為一新近引進之麻醉藥，其具有快速平穩及迅速恢復之特性。使用此藥最常見之副作用為在注射時所造成的注射疼痛及不舒服，根據報告有許多方法可以減輕疼痛程度，包括有麻醉前給藥，注射之位置及速度，合併使用或先前注射局部麻醉劑及使用低温propofol注射劑。此研究在比較及評估三種不同方式的減輕疼痛效果，結果顯示合併使用及先前注射局部麻醉劑皆可以明顯地減低注射時所引發之疼痛及不舒服，而使用低温注射劑只有減低疼痛而無減少不舒服之發生率。