The use of flipped classroom concepts for classroom teaching reform is of great significance for improving the quality of talent training in applied undergraduate colleges. "Signal and System" course is the main professional basic course of electronic information major, which is a key course for application-oriented undergraduates to cultivate application-oriented talents. The traditional classroom teaching model has seriously affected students' ability to absorb and digest knowledge. With the help of flipped classroom concept, three strategies are proposed in this paper for teaching reform, including the integration of curriculum and teaching, the construction of collaborative innovation for learning activities, the rebirth of "learning and teaching" concept. It is expected to improve students’ understanding and application about the course to meet the requirements of applied undergraduate colleges for talent training.