- 學位論文
多區域成長法應用於MRI T2 影像評估水腦體積比率之研究
Evaluating the Ratio of Volume for Hydrocephalus with MRI T2 Image by MSRG Algorithm
摘要
磁振造影腦影像對於水腦症與腦部疾病均具有良好的鑑別診斷。目前，利用磁振造影腦部影像進行規律健檢者逐漸增加，臨床上常用磁振造影做為水腦症診斷主要工具，在於磁振造影具有非侵入性、無輻射線傷害、安全與提供精準影像等優勢，建立影像特徵之分析模型，期能提供診斷參考資訊。 本研究採用分組回顧性研究收集 2007 年1 月至 2016 年12 月共計60例(男42人，女18人) 執行已確診為水腦(n=30)與對照正常腦室磁振造影(Magnetic Resonance Imaging, MRI)影像之患者(n=30)。接著利用多區域成長法(Multiple Seeding Region Growing, MSRG)評估MRI影像水腦體積佔全腦之比率；本研究目的為利用分類探勘之多種子區域成長法進行磁振造影腦部體積影像評估，並提供一個準確且可信賴的輔助定量資訊。結合羅吉斯特回歸模型、描述性統計、接收者操作特徵曲線資料分類方法，同時估算不同分類影像特徵之風險，期能提供臨床影像定量分析參考資訊。 本次研究了解影像特徵值具有顯著性；可藉由實驗組與對照組估計出水腦症與正常腦室體積之間的臨界點為484.651c.c.。在多區域種子成長法得知六個種子是本研究最佳化體積比率為0.996，由於本次研究樣本數量有侷限，期許未來可以長期收集MRI影像，以提高分析可靠性與準確性。
並列摘要
Magnetic Resonance Imaging of the brain is a high-quality tool for facilitating diagnosis of hydrocephalus and other brain diseases. A trend toward using MRI of the brain as a regular checkup item has gradually emerged. Clinically, MRI is often used as a primary tool for diagnosing hydrocephalus because of numerous advantages: it is safe and non-invasive, incurs no radiation damage, and provides accurate images. This study aimed to establish an image analysis model to serve as a reference for diagnosis. In this study, 60 patients (42 males and 18 females) were enrolled between February 2007 and December 2016 in which 30 patients with hydrocephalus (n=30) comapared with control group (n=30) .After that, the ratio of cerebrospinal fluid volume to total brain in MRI images was evaluated by (Multiple Seeding Region Growing, MSRG) .The purpose of this study was to access brain volume using MSRG method, as well as provide accurate and reliable quantitative information. Combined with Logistic Regression mode, descriptive statistics,Receiver Operating Characteristic data classification method, in the meantime estimating the risk of different classification of image features, provide reference for clinical imaging quantitative analysis. The significant features of image were investigated in this study. The critical point between hydrocephalus and healthy brain ventricle volume was estimated to be 484.651 cc based on comparison of the experimental and control groups. Multiple Seeding Region Growing approach was used to determine optimal volume ratio 0.996 by the six seeds. This study was limited by the number of samples. Future studies should collect MRI images with long-term to improve the reliability and accuracy of image analysis.