肺支氣管發育不全的新觀念－血管生成不良假說

Bronchopulmonary Dysplasia (BPD)-Vascular Hypothesis of BPD

林毓志(Yuh-Jyh Lin) ； 林其和(Chyi-Her Lin)

《中華民國兒童胸腔醫學會雜誌》 5卷3期 (2007/05) Pp. 117-121

https://doi.org/10.6322/JPRD.200705_5(3).0003

摘要

無資料

關鍵字

肺支氣管發育不全 ； 血管內皮細胞生長因子 ； 內皮細胞一氧化氮合成媒 ； 一氧化氮 ； 血管生長

並列摘要

Bronchopulmonary dysplasia (BPD) is the chronic lung disease of infancy that follows ventilator and oxygen therapy for acute respiratory failure after premature birth. Recently, infants with ”New BPD” have a far different clinical course and pathology than had been observed in infants with ”classic BPD” in the past. Infants with ”New BPD” now have less severe acute respiratory disease, and at autopsy, lung histology is predominantly characterized by arrested lung development, including impaired alveolar and vascular growth.
Mechanisms that inhibit distal lung growth are poorly understood, but recent clinical and laboratory studies suggest that impaired vascular endothelial growth factor signaling and reduced nitric oxide (NO) production decreases alveolar and vessel growth in the developing lung, features observed in experimental oxygen-induced BPD. Therapy enhancing VEGF/NO signaling may be a potential way to treat diseases associated with impaired alveolar structures.

並列關鍵字

Bronchopulmonary dysplasia ； Vascular endothelial growth factor ； endothelial Nitric oxide synthase ； Nitric oxide ； Angiogenesis ； Alveolarization