We wanted to know if the serum urea nitrogen to creatinine ratio (BUN/Cr) could help distinguish upper from lower gastrointestinal bleeding. We retrospectively analyzed patients admitted to our hospital for gastrointestinal bleeding over the past two years. A total of 114 patients represented 90 upper bleeds, 24 lower bleeds, and 30 healthy cases for control. The serum BUN/Cr ratio on admission was significantly higher in upper than in lower bleeds and control cases [113.3±9.3, 59.4±24, and 64.4±12 respectively (p<0.001)]. Regardless of blood volume loss, no lower bleeds or healthy cases had a ratio of ≥95, whereas, 65 of 90 (72.2%) of the upper bleeds had a ratio of ≥95. The ≥95 serum BUN/Cr ratio in upper bleeds continued until the third day after bleeding. This simple ratio may be valuable in determining the sequence of investigations in patients with an unidentified source of gastrointestinal bleeding.
We wanted to know if the serum urea nitrogen to creatinine ratio (BUN/Cr) could help distinguish upper from lower gastrointestinal bleeding. We retrospectively analyzed patients admitted to our hospital for gastrointestinal bleeding over the past two years. A total of 114 patients represented 90 upper bleeds, 24 lower bleeds, and 30 healthy cases for control. The serum BUN/Cr ratio on admission was significantly higher in upper than in lower bleeds and control cases [113.3±9.3, 59.4±24, and 64.4±12 respectively (p<0.001)]. Regardless of blood volume loss, no lower bleeds or healthy cases had a ratio of ≥95, whereas, 65 of 90 (72.2%) of the upper bleeds had a ratio of ≥95. The ≥95 serum BUN/Cr ratio in upper bleeds continued until the third day after bleeding. This simple ratio may be valuable in determining the sequence of investigations in patients with an unidentified source of gastrointestinal bleeding.