Background: Selective internal radiation therapy (SIRT) with yttrium-90 (Y-90) loaded microspheres has been widely used as a locoregional therapy for liver tumors. After SIRT, Y-90 positron emission tomography (PET) is performed to verify microspheres delivery and detect any significant extrahepatic activity. However, the image quality of Y-90 PET is usually poor because of low count statistics and high noise. Q.Clear (GE Healthcare, Milwaukee, WI, USA) is a new Bayesian penalized likelihood reconstruction algorithm that suppresses noise by a penalization factor (termed β). The aim of this study is to compare Q.Clear with conventional reconstruction methods and assess the optimal β value of Q.Clear for visual and quantitative evaluation of Y-90 PET in patients after SIRT. Methods: From July 2019 to August 2020, 13 patients with 30 liver tumors were enrolled. A total of 12 reconstruction methods were used, including ordered subset expectation maximization (OSEM), OSEM with point spread function (PSF), OSEM with time of flight (TOF), OSEM with PSF and TOF, Q.Clear with β values of 500, 1,000, 2,000, 3,000, 4,000, 5,000, 6,000, and 8,000. Quantitative image analyses of the contrast, noise, and signal to noise ratio (SNR) were calculated for comparison. Visual scoring of image quality was also performed. Results: Applying PSF resulted in significantly higher contrast and SNR (both p < 0.001). There was no significant difference in contrast, noise, or SNR between images with and without TOF. In Q.Clear, increasing β value resulted in reduced noise, thereby improving SNR. Compared to OSEM with PSF and TOF, Q.Clear with β values above 2,000 had significantly lower noise (all p < 0.001) and higher SNR (all p < 0.001). All Y-90 PET images had acceptable image quality using Q.Clear with β values of 4,000, 5,000, and 6,000. Conclusions: Our results indicate that Q.Clear with β values between 4,000 and 6,000 had lower noise, higher SNR, and image quality more acceptable than conventional OSEM-based reconstruction methods in post-SIRT Y-90 PET.
背景:本研究目的為骨質密度和骨小樑指數(trabecular bone score, TBS)是否與50歲以上女性的血清鹼性磷酸酶(alkaline phosphatase, ALP)數值相關。方法:本篇為回溯性研究,收集2014年11月至2021年7月於臺灣南部某教學醫院預防醫學中心接受健康檢查之女性。排除標準:包括年齡<50歲、尚未停經、癌症、人體測量或實驗室數據不完整、骨質密度數據不完整。最終收集7,188位停經後婦女。數據分析,參與者根據骨密度分為三組:正常骨密度883位(12.1%);低骨質密度3,687位(51.3%);骨質疏鬆症2,618位(36.4%)。結果:本篇研究平均年齡為61.27±6.97歲(範圍51-88歲)。整體平均身體質量指數為23.72±3.33 kg/m^2,平均ALP為80.59±23.34 IU/L,平均TBS為1.301±0.095。數據分析顯示,低骨質密度組ALP數值為正常組的1.289倍(p<0.001*),而骨質疏鬆組是正常組的1.599倍(p<0.001*)。在TBS低骨密度組為正常組的0.313倍(p<0.001*),而骨鬆組為正常組的0.111倍(p<0.001*)。多元線性回歸逐步分析顯示,TBS和ALP具有顯著的反比關係。結論:在50歲以上女性中,我們觀察到ALP數值越高,TBS和骨質密度越低。
An 83-year-old woman underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography for non-invasive evaluation of pleural effusion and pericardial effusion. The scan incidentally revealed an FDG-avid lesion in the right breast with lymph nodes in the right internal mammary chain. Core needle biopsy on the same day showed foamy histiocytes infiltration mixed with foreign-body type giant cells, pigmentation, cholesterol clefts, and inflammatory cell infiltration, indicating xanthogranulomatous mastitis. Cytokeratins AE1/AE3 immunostain was negative, which indicated no evidence of malignancy. There is no definite evidence of tumor growth in the right breast during a 2-year follow-up.
A 52-year-old woman had non-painful palpable hard mass 5.5 × 6.0 × 1.0 cm for years, weight loss (from 80 to 62 kg), low appetite, bilateral loin-to-low-back pain, and loose stools for 2 months. Mammography showed right breast stationary upper outer quadrant focal asymmetry and small round calcification, Breast Imaging Reporting and Data System (BIRADS) category 2. ^(18)F-fluorodeoxyglucose positron emission tomography-computed tomography showed uptake in the stomach, cecum, T-colon, right breast, right axillary lymph nodes, axial and appendicular skeletons. Panendoscopy and colonoscopy showed 2 gastric polypoid lesions and subepithelial tumor-like appearance at cecum and T-colon; biopsy at 4 sites showed poorly-differentiated metastatic carcinoma, consistent with the breast origin. Right lateral breast core needle biopsy showed invasive lobular carcinoma.
A 79-year-old man with 2 parathyroid carcinomas in the left inferior and perithyroid regions received left thyroidectomy, parathyroidectomy, and mediastinal tumor excision on 2017/12/18 (pT1(2)N0(0/1)M0 [AJCC, 2017]). Nine months later, gradually elevated calcium and intact parathyroid hormone were noted. Dual-phase whole body MIBI scan with routine parathyroid scan and delayed single photon emission computed tomography/computed tomography (SPECT/CT) showed 1 abnormal focus with persistent accumulation of radiotracer in the supra-manubrial region. Planar imaging showed prominent visualization of the right thyroid bed initially with normal washout in delayed images, and no other prominent focus in whole body survey. Ultrasound-guided biopsy of anterior neck soft tissue showed recurrent parathyroid carcinoma.
為了持續優化網站功能與使用者體驗,本網站將Cookies分析技術用於網站營運、分析和個人化服務之目的。
若您繼續瀏覽本網站,即表示您同意本網站使用Cookies。