Asian Journal of Anesthesiology
- OpenAccess
- Ahead-of-Print
台灣麻醉醫學會 & Ainosco Press,正常發行
選擇卷期
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- OpenAccess
Objective: Deep sedation without intubation for termination of first trimester pregnancy of suction evacuation entails use of sedatives such as propofol or a combination of propofol and sulfentanil, with unwanted complications. Dexmedetomidine is an α_2-adrenorecepter agonist which provides sedation, anxiolysis and analgesia, without any of the complications associated with the popular sedatives. Methods: A total number of 90 patients were randomized to three groups: (1) group P, treated with intranasal saline, intravenous saline and propofol; (2) group DP, treated with intranasal dexmedetomidine, intravenous saline and propofol; and (3) group SP, treated with intranasal saline, intravenous sulfentanil and propofol. The primary outcome was the consumption of propofol, and the secondary outcomes were numeric rating scale (NRS) anxiety score, NRS pain score of uterine cramping, amount of blood loss, use of oxytocin and NRS satisfaction scores of obstetric and gynecological (ob/gyn) physicians and patients. Results: The consumption of propofol, NRS pain score of uterine cramping after surgery, NRS anxiety score, and amount of blood loss in group DP were significantly lower than those in group P and group SP. Ob/gyn physicians' satisfaction score in group DP was significantly higher compared with group SP and group P. Conclusion: Sedation with intranasal dexmedetomidine (1 μg/kg) provided effective analgesia and anxiolysis, reduced consumption of propofol and lower blood loss in termination of first trimester pregnancy of suction evacuation. Compared with propofol or the combination of propofol and sulfentanil, intranasal dexmedetomidine was associated with higher satisfaction score of ob/gyn physicians. No unforeseen perioperative respiratory and cardiovascular adverse events occurred.
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Objective: Sepsis-related systemic inflammation resulted in microcirculatory dysfunction. However, information of normal ranges of microcirculatory parameters in the healthy population remain limited. The primary aim of this study was to investigate the differences in microcirculatory parameters between healthy volunteers and patients with sepsis. Methods: This observational study enrolled 45 healthy female and 45 healthy male volunteers, and divided them equally into three age groups: young (20-39 years), middle-age (40-59 years), and elderly (60-79 years). In addition, we enrolled 32 patients with sepsis. Images of sublingual microcirculation were obtained through sidestream dark field videomicroscopy and were analyzed using automated analysis software. Microcirculation parameters, namely the total small vessel density (TSVD), perfused small vessel density (PSVD), proportion of perfused vessel (PPV), microvascular flow index (MFI) score, and heterogeneity index (HI), were evaluated. One-to-one matching between the septic patients and the healthy volunteers was performed on the basis of demographic data including age and gender. Results: The elderly group had lower MFI scores and a higher HI. Age was positively correlated with the HI (r = 0.38, p ＜ 0.001) and negatively correlated with the PPV and MFI scores (r = -0.26, p = 0.014 and r = -0.37, p ＜ 0.001, respectively). TSVD was higher in female participants than in male participants. Body mass index (BMI) was negatively correlated with TSVD. In multivariate regression analysis, the independent factors associated with PPV are age and sex, however age is the only independent factor associated with MFI and HI. In patients with sepsis, TSVD (17.5 [3.3] vs. 21.7 [3.0]; p = 0.002), PSVD (15.0 [3.0] vs. 21.1 [2.5]; p ＜ 0.001), and MFI score (2.0 [1.6-2.5] vs. 2.9 [2.5-3.0]; p ＜ 0.001) were lower in the 28-day nonsurvivors than in the survivors. Matched comparison revealed that the TSVD (20.7 [3.7] vs. 25.2 [2.3]; p ＜ 0.001), PSVD (19.8 [3.0] vs. 24.3 [2.7]; p ＜ 0.001), and MFI score (2.7 [2.4-3.0] vs. 3.0 [2.7−3.0]; p = 0.019) were lower in the patients with sepsis than in the healthy volunteers. Conclusion: Age and sex were correlated with microcirculatory parameters of the healthy volunteers. In the patients with sepsis, microcirculatory dysfunction was more severe in the 28-day nonsurvivor group than in the 28-day survivor group. Furthermore, the patients with sepsis exhibited significantly lower TSVD, PSVD, and MFI scores than the healthy volunteers.
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Objective: Postdural puncture headache (PDPH) is the most common serious complication in obstetric anesthesia. We show the incidence of accidental dural puncture (ADP), PDPH, epidural blood patch (EBP) and associated morbidity following a protocol established in an obstetric anesthesia department. Methods: An observational, prospective, analytical study performed in 66,540 epidural labor analgesia procedures. The objective is to describe the incidence of ADP, PDPH and EBP in a large obstetric anesthesia population, as well as morbidity associated with ADP and EBP. Results: Incidence of ADP and PDPH was 0.76% and 59%, respectively, and the global incidence of EBP was 0.2%. Experience of the anesthetist performing the epidural (1st or 2nd year resident) and night shift were correlated with ADP. Low back pain was more frequent in patients undergoing EBP. Conclusion: We found an incidence of ADP and PDPH of 0.76% and 59%, respectively. Experience of the anesthetist performing the epidural (1st or 2nd year resident) and night shift were correlated with ADP. EBP is a safe, easy and acceptable treatment for PDPH, despite a higher risk of low back pain
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Objective: Postoperative pneumonia is the third most common postoperative complication. It may result from aspiration of secretions accumulating in the subglottic space during general anesthesia (GA). However, the relationship between endotracheal suctioning (ETS) during extubation from GA emergence and postoperative pneumonia has not been well investigated. Therefore, the aim of this study was to investigate the effectiveness of ETS during extubation in prevention of postoperative pneumonia in ophthalmic surgery under GA in our medical center from 2011 through 2015. Methods: Three thousand, seven hundred and ninety-four patients receiving ophthalmic surgery under GA were included and divided into two groups by the anesthesiologists. The first group underwent the conventional ETS during extubation, while the other group was extubated without ETS. The incidences of postoperative pneumonia were compared between the two groups to find the correlation between ETS during extubation and postoperative pneumonia. In addition, other complication such as postoperative hemorrhage was also recorded. Results: Of the 3,794 patients undergoing ophthalmic surgery under GA, 2,187 (58%) patients underwent extubation with ETS, whilst 1,607 (42%) patients were extubated without ETS. The incidence rates of postoperative pneumonia with or without ETS during extubation were both 0%. Besides, the incidence rates of postoperative hemorrhage were also both 0% in two groups. Conclusion: Extubation from GA without ETS seemed not to increase the risk of postoperative pneumonia. Thus, no routine ETS during extubation seemed not to be a risk factor for postoperative pneumonia under GA in ophthalmic surgery.