- 期刊
Küttner氏腫瘤（慢性硬化唾液腺炎）
Küttner's Tumor (Chronic Sclerosing Sialadenitis)
摘要
慢性硬化唾液腺炎(chronic sclerosing sialadenitis)，又名Küttner氏腫瘤(Küttner's tumor)，爲一種慢性發炎的唾液腺疾病，好發於下頜下腺，而腮腺及小唾液腺亦爲可能的病灶位置。Küttner氏腫瘤爲無痛腫脹或反覆性疼痛腫脹的硬實唾液腺腫塊，臨床特徵難以與其他唾液腺腫瘤區分，須以病理組織檢查辨明。其組織學特徵是漸進式管道周圍硬化、腺泡萎縮、以及腺體發生淋巴球浸潤。近來的研究指出Küttner氏腫瘤的發炎反應以T淋巴球爲主，且可能與自體免疫反應有關。目前治療Küttner氏腫瘤的方法爲發炎腺體的摘除。本文內容報告國泰綜合醫院從1997-2008年所經歷的3例Küttner氏腫瘤的病例，亦同時回顧文獻，對Küttner氏腫瘤的病因、症狀、治療、組織學特點及鑑別診斷等做了整理與討論，以期讀者對此疾病有更深入的了解。
並列摘要
Chronic sclerosing sialadenitis, also known as Küttner's tumor, is a benign tumorlike lesion predominately involving the submandibular gland. Parotid and other minor salivary glands could be affected as well. The lesion is clinically characterized by a firm, painful or painless swelling of the gland. Clinically, the disease cannot be distinguished from a true neoplasm. The definite diagnosis depends on pathological diagnosis. Recent studies indicated that the inflammatory process is T-cell predominated. Submandibular sialadenectomy is a safe and effective treatment of Küttner's tumor. We report 3 casesof Küttner's tumor that involved submandibular glands in our hospital from 1993 to 2008. The etiology, pathogenesis, histological and clinical characteristics of this diseaseare discussed and presented.