Effect of Lead on the Fertility of Male Mice

鉛對雄鼷鼠之生殖力的影響

郭宗甫(Tzong-Fu Kuo) ； 張肇先(Chau-Hsien Chang) ； 劉鎮發(Chun-Fat Lau)

《中華民國獸醫學會雜誌》 22卷3期 (1996/06) Pp. 145-152

https://doi.org/10.7009/JTCSVS.199606.0145

摘要

已知重金屬如鉛會引起雄性生殖系統的病變，然而是否這有毒的作用對活的生殖細胞能造成任何遺傳的致害尚無充分研究。本研究旨在使用顯性致死試驗（Dominant lethal test）來分析並評估鉛對雄鼷鼠之生殖細胞的影響。雄鼷鼠經腹腔注射單一劑量每位斤體重100 mg或50 mg醋酸鉛後分別在第二週時短暫喪失其授孕能力，到了注射第三週後又恢復正常。醋酸鉛注射後第十五週雄鼷鼠睾丸的組織病理切片研究顯示正常。本研究結論是鉛即使是在致死下濃度對雄性生殖細胞將僅發生暫時性的中毒。

關鍵字

鉛 ； 生殖力 ； 雄鼠

並列摘要

Heavy metal such as lead is well known to cause lesions of the male reproductive system. Whether this deleterious effects can produce genetic hazards in surviving germ cells is not well-understood. Therefore, we used dominant lethal study to test the effect of lead on germ cells of male mice. Mice injected intraperitoneally with lead acetate (100 mg/kg or 50 mg/kg) had a decreased rate of mating for 2 weeks and fertility was reduced transient\y. Three weeks after the treatment, the fertility was resumed to normal. Histopathological studies showed that the testes were normal after the experiment was completed. We conclude that lead is only transiently toxic to the male reproductive cells even at sub-lethal concentrations.

並列關鍵字

Lead ； Fertility ； Male mice