Salinomycin對紐西蘭白兔的毒性及人工混合感染兔腸型球蟲之藥效

Toxicity and Anticoccidal Activity of Salinomycin in New Zealand White Rabbits

何素鵬(Shu-Peng Ho) ； 何麗玲(Lih-Ling Ho) ； 董光中(Kwong-Chung Tung) ； 王渭賢(Way-Shyan Wang)

《中華民國獸醫學會雜誌》 26卷1期 (2000/03) Pp. 43-55

https://doi.org/10.7009/JTCSVS.200003.0043

摘要

Toxicity and anticoccidial effects of salinomycin were studied in New Zealand white rabbit (Orycotolagus cuniculus). The results of the toxicity test revealed that rabbits fed with salinomycin at 20 and 40 mg/kg bw/day were found to have reduced feed conversion ratio by 33.1%, and 41.9%, respectively (P＜0.05) during 36 trial days. The results of histological observations of the treated rabbits showed that vesicular degeneration of hepatocytes, myopathies, and hyaline degeneration of leg muscle fibers and renal tubules. Drug treatment resulted in elevations in biochemical blood parameters, such as the values of AST, LDH, CK, BUN, and creatinine. The mortality caused by salinomycin at 20 mg/kg bw/day was 17% (1/6). The no-observed-adverse-effect level of salinomycin in rabbits was found to be 5 mg/kg bw/day. Efficacy trial was performed by first giving each rabbit the drug for 3 days followed by challenging orally with 7 × 10^3 /sporulated oocysts of intestinal coccidia (Eimeria intestinalis, E. magna, E. media, and E. perforans) and then treating with the same drug for 14 days. The following doses of salinomycin: 3, 4.5, and 6 mg/kg bw/day; were administered to rabbits. In the efficacy trials, the feed conversion ratio in non-treated but infected group of rabbits was found to be 224% lower than that of the non-treated uninfected animals (control group). In addition to a lesion score of 15.3 and 80% (4/5) mortality. In infected but treated with salinomycin at 4.5 mg/kg bw/day group of animals a weight gain of 3% coupled with no differences in feed consumption and feed conversion was observed as compared with the control group. The average of weekly peak oocyst output of the treated group was (5 ± 0.8) 10 ^6 /oocyst per gram feces (O.P.G.), while in the untreated infected group it was (1.0 ± 0.2) 10^6 /O.P.G. Thus, salinomycin at 4.5 mg/kg bw/day was found to be safe and effective against the intestinal coccidiosis in rabbits.

關鍵字

抗球蟲藥 ； 球蟲症 ； 紐西蘭白兔 ； 毒性

並列摘要

Toxicity and anticoccidial effects of salinomycin were studied in New Zealand white rabbit (Orycotolagus cuniculus). The results of the toxicity test revealed that rabbits fed with salinomycin at 20 and 40 mg/kg bw/day were found to have reduced feed conversion ratio by 33.1%, and 41.9%, respectively (P＜0.05) during 36 trial days. The results of histological observations of the treated rabbits showed that vesicular degeneration of hepatocytes, myopathies, and hyaline degeneration of leg muscle fibers and renal tubules. Drug treatment resulted in elevations in biochemical blood parameters, such as the values of AST, LDH, CK, BUN, and creatinine. The mortality caused by salinomycin at 20 mg/kg bw/day was 17% (1/6). The no-observed-adverse-effect level of salinomycin in rabbits was found to be 5 mg/kg bw/day. Efficacy trial was performed by first giving each rabbit the drug for 3 days followed by challenging orally with 7 × 10^3 /sporulated oocysts of intestinal coccidia (Eimeria intestinalis, E. magna, E. media, and E. perforans) and then treating with the same drug for 14 days. The following doses of salinomycin: 3, 4.5, and 6 mg/kg bw/day; were administered to rabbits. In the efficacy trials, the feed conversion ratio in non-treated but infected group of rabbits was found to be 224% lower than that of the non-treated uninfected animals (control group). In addition to a lesion score of 15.3 and 80% (4/5) mortality. In infected but treated with salinomycin at 4.5 mg/kg bw/day group of animals a weight gain of 3% coupled with no differences in feed consumption and feed conversion was observed as compared with the control group. The average of weekly peak oocyst output of the treated group was (5 ± 0.8) 10 ^6 /oocyst per gram feces (O.P.G.), while in the untreated infected group it was (1.0 ± 0.2) 10^6 /O.P.G. Thus, salinomycin at 4.5 mg/kg bw/day was found to be safe and effective against the intestinal coccidiosis in rabbits.

並列關鍵字

Anticoccidal drug ； Coccidiosis ； Rabbit ； Salinomycin ； Toxicity