中孔洞氧化矽薄膜於不同尺度變因下對於客體分子的吸附與釋放行為之影響

A Hierarchical Study on Load/Release Kinetics of Guest Molecules into/from Mesoporous Silica Thin Films

連泓原(H. Y. Lien) ； 吳嘉文(C. W. Wu)

《鑛冶：中國鑛冶工程學會會刊》 56卷3期 (2012/09) Pp. 128-137

https://doi.org/10.30069/MM.201209.0011

摘要

此篇研究關注於中孔洞薄膜作為藥物載體，其本身條件對於客體分子的吸附與釋放行為之影響。在吸附行為中，配合吸附動力曲線以及等溫吸附曲線來比較不同孔洞結構薄膜的吸附行為、脫附常數、及最大裝載量。在釋放行為中，比較了三個不同尺度的變因，分別為薄膜圖樣化、中孔洞結構、藥物裝載方式。實驗結果顯示，圖樣化的薄膜由於孔道內的擴散路徑變短，因此具有快速且大量的釋放。在中孔洞結構中，由於孔洞在三維空間的相似性，故二維與三維六角堆疊孔洞結構的釋放行為並無太大差異。在藥物裝載方式中，則比較物理吸附、夾雜及可斷式鍵結等三種，並應用Peppas方程式來描述並比較其釋放行為。結果顯示，以物理吸附客體分子，其釋放受到分子在孔道內質傳速率的限制；夾雜手法的釋放則受到界面活性劑溶解速率的限制；可斷式鍵結則可利用外加刺激物來切斷薄膜與客體分子間的鍵結，可以達到任意控制釋放的起始時間點。

關鍵字

中孔洞材料 ； 薄膜 ； 藥物輸送 ； 控制釋放

並列摘要

This research focuses on the load/release behaviors of model drug, using mesoporous silica thin films as hosts. Adsorption kinetics and binding isotherms were determined to obtain the adsorption profiles, dissociation constants, and maximum adsorption amounts. Three hierarchical parameters, morphologies of thin film, mesostructures, and loading methods were compared to investigate the adsorption behavior. The patterned films showed burst release at beginning because of shorter diffusion path. The 2D and 3D hexagonal mesostructures made no significant differences on release kinetics. The model drug was loaded in three different ways: physical adsorption, entrapment, and cleavable binding. The release behaviors were analyzed using Peppas equation. In physical adsorption, the adsorbed model drug released in diffusion-controlled release; in entrapment, the model drug released in dissolution-controlled release; in cleavable binding, the release timing of bound model drug could be controlled by adding stimulants.

並列關鍵字

mesoporous materials ； thin film ； drug delivery ； controlled release