The assessment and prevention principles of occupational disorders, including occupational injuries and occupational illnesses, in the postural control system are reviewed in this article. A working posture is a position adopted because it is appropriate for the task being performed. In this article, the lower back, knee, and standing balance control are included as the postural control system. The postural control system may be affected by work-related factors to cause fatigue, pain, and loss of stability. A systems perspective model of work-related postural control system disorders was proposed. It was suggested that personal, environmental, and task factors should be systematically reviewed in order to identify the influencing factors leading to occupational disorders. Assessment tools including questionnaire, observation, checklists, modified OWAS video analysis system, lumbar motion monitor, electromyographic systems, and force plate systems used in occupational settings were reviewed. The reliability and validity, cost, generality and specificity factors should be considered when selecting an appropriate assessment tool. Effective prevention programs considers the same systems that are reviewed in the systems model. Principles of ergonomics, neuromuscular control of posture, are a few factors important for prevention of occupational disorders. The authors suggest physical therapy professionals to participate in the management of work-related disorders as an occupational medicine health care member.