Reversible Dementia Induced by Primary Hyperparathyroidism-related Hypercalcemia after Parathyroidectomy -A Case Report

原發性副甲狀腺高能症導致高血鈣相關之痴呆症－病例報告

王治元(Chih-Yuan Wang) ； 張天均(Tien-Chun Chang) ； 趙世晃(Hse-Huang Chao)

《慈濟醫學雜誌》 8卷2期 (1996/06) Pp. 145-149

https://doi.org/10.6440/TZUCMJ.199606.0145

摘要

因副甲狀腺高能症及其它代謝性障礙導致的高血鈣症可引起神經系統的症狀，其中包括癡呆及巴金森氏症。許多證據顯示高血鈣可於中樞神經系統造成細胞的毒性效應，而扮演導致神經精神症狀之重要角色。但是原發性副甲狀腺高能症之高血鈣完全以癡呆作為臨床表現者，卻是相當罕見，並且少有報告。我們報告一位病患，臨床上被診斷為阿茲海默氏癡呆症達三年之久，而後發現有高血鈣症，並證實為續發於副甲狀腺腺瘤。在切除副甲狀腺腺瘤後，病人完全恢復郅正常的意識狀態及正常的社會功能。

關鍵字

癡呆症 ； 副甲狀腺高能症 ； 高血鈣

並列摘要

Hypercalcemia due to hyperparathyroidism or other metabolic disorders is recognized as a cause of neurological disturbances, including dementia and parkinsonism. Thus, a hypercalcemia-induced cytotoxic effect in the central nervous system may play an important role in neuropsychiatric manifestations. However, there have only been rare prion reports of primary hyperparathyroidism manifestating as dementia. We report a patient who was noted to have progressive dementia for three years. Hypercalcemia was later noted in routine biochemical evaluation. After removal of a parathyroid adenoma, mentality returned to normal status and dementia disappeared completely.

並列關鍵字

dementia ； hyperparathyroidism ； hyperalcemia