Successful Treatment of Aspergillus Sinusitis with Oral Voriconazole: A Case Report

口服性Voriconazole治療鞠菌性鼻竇炎之成功案例：病例報告

卓士傑(Shih-Jie Jhuo) ； 王威勝(Wei-Sheng Wang) ； 郭任遠(Jen-Yuan Kuo)

《內科學誌》 22卷1期 (2011/02) Pp. 63-68

https://doi.org/10.6314/JIMT.2011.22(1).08

摘要

鞠菌性鼻竇炎(Apergillus sinusitis)若無適當的治療，能造成極高的致死率。此疾病不僅能在免疫力受損的病人上發現，有時也能在免疫力健全的病人上發現。臨床上，治療鞠菌性鼻竇炎的方法包括外科手術及給予以靜脈注射或是口服抗黴菌抗生素，包括了傳統上靜脈注射amphotericin B。在此病例報告中，我們將敘述一位病人感染鞠菌性鼻竇炎並造成上頜骨及周邊眼框骨(maxillary and orbital bone)的破壞。經外科手術治療後，因病人腎臟功能不佳而給予口服voriconazole治療成功的案例。在33天給予voriconazole 400mg/day治療後，病人的感染症狀完全改善，並無明顯的後遺症發生。

並列摘要

Aspergillus sinusitis is an infection that can cause high mortality without appropriate treatment. The infection is not only found in immunocompromised patients, but also in immunocompetent patients. Management approaches to Aspergillus sinusitis include surgical debridement and intravenous or oral antifungal agents, including traditional intravenous amphotericin B. Here we describe a case of Aspergillus sinusitis with maxillary and orbital bony destruction. After surgical debridement, oral voriconazole was given to this patient due to the fact that he had poor renal function. After he had been administered with voriconazole 400 mg/day for 33 days, the infection was resolved completely.

並列關鍵字

Aspergillosis ； Sinusitis ； Voriconazole