目標化磁共振造影劑之現況與展望

Status and Prospect of Targeting Contrast Agents in Magnetic Resonance Imaging

王雲銘(Yun-Ming Wang) ； 陳小鳴(Hsiao-Ming Chen) ； 鄭武隆(Wu-Long Cheng)

《中華放射線醫學雜誌》 19卷1期 (1994/03) Pp. 81-96

摘要

本報告係針對近年來目標化造影劑在磁共振造影術醫學應用研究發展做一綜合回顧，主要內容包括順磁性金屬錯合物、超順磁鐵氧化物、巨大分子造影劑如polylysine、勝肽及多醣類，以及標幟鐵氧化合物之受體及抗體。目前已發展之造影劑大部分以非目標化之釓、鐵及錳等金屬錯合物爲主，而目標化之造影劑如針對受體、抗體及細胞之特殊性，將可應用於特殊疾病之診斷及器官功能之定量評估，本研究主題將是未來十年積極發展之重心，目前已有幾種目標化磁共振造影劑正進行動物實驗中，本文亦做詳細介紹。

關鍵字

磁共振造影劑 ； 磁共振抗體造影術 ； 對比劑

並列摘要

The targeting contrast agents used in magnetic resonance imaging were reviewed in this paper. The contents included paramagnetic metal ion chelates, superparamagnetic iron oxides, macromolecular contrast media containing polylysine, peptides, polysaccharides, and receptor and antibody labeled with superparamagnetic particle. Currently most pieces of work in this field are performed in the small molecular of iron, manganese or lanthanide chelates. The receptor, antibody, peptide and cell specificity are expected to be more important for functional magnetic resonance imaging in the next decade. Several target-specific MR agents have already been tested in animals. The individual components of these MR contrast agents and their promising applications are described.

並列關鍵字

Contrast medium, MR ； magnetic resonance, antibody imaging ； magnetic resonance, contrast enhancement