Serum Soluble Interleukin-2 Receptor Levels of Normal Subjects and Uveitis Patients

正常人及葡萄膜炎患者血清第二介白質受器濃度之測定

楊長豪(Chang-Hao Yang) ； 劉寬鎔(Kwan-Rong Liu) ； 吳明修(Ming-Shiou Wu) ； 陳慕師(Muh-Shy Chen)

《中華民國眼科醫學會雜誌》 32卷2期 (1993/06) Pp. 141-145

https://doi.org/10.30048/ACTASOS.199306.0001

摘要

受到第二介白質刺激後之T淋巴球，可在其表面產生第二介白質受器(IL-ZR)，同時釋放可溶性之IL-2R於血清中，測定血清中之IL-2R濃度可間接反應組識免疫反應之程度。我們利用酵素連接免疫吸附法(ELISA)測定正常人及內因性葡萄膜炎患者之血清IL-2R濃度。七位正處於急性期之病患，其IL-2R平均值為2100±1085 unit/ml十一位處於非急性期之患者，其IL-2R平均值為341±71 unit/ml和正常人之平均值437±95 unit/ml在統計上並無差異。由我們初步之結果可知，血清IL-2R濃度可隨葡萄膜炎之活性而變動，測定葡萄膜炎病人之血清IL-2R濃度可提供評估此種疾病活性之重要臨床指標。

並列摘要

Interleukin-2 receptor (IL-2R) is expressed on the activated T cell after stimulation by interleukin-2 (IL-2), a potent immune growth factor. Meanwhile a soluble form of IL-2R is released into serum. Detection of serum IL-2R levels reflects the immune response of the tissue. We used enzyme-linked immunoabsorbent assay (ELISA) to determine the serum IL-2R levels of endogenous uveitis patients and normal subjects. Seven uveitis patients with active disease had the mean serum IL-2R level of 2100±1085 unit/ml. The mean of IL-2R of eleven patients with inactive disease was 341±71 unit/ml which was not different from that of control group (437±95 unit/ml) significantly. From our preliminary results, we suggested that serum IL-2R levels were associated with the disease activity of uveitis, and measurement of serum IL-2R levels in uveitis patients provided a promising way to monitor the disease activity of uveitis patients.

並列關鍵字

Interleukin-2 receptor ； Uveitis ； Enzyme-linked immunoabsorbent assay