- 期刊
Isolation and Identification of a Vardenafil Analogue in a Dietary Supplement
保健食品中摻加樂威壯類緣物成分之純化與鑑定
摘要
一種暗示具壯陽效果之保健食品，首次檢出非法摻加樂威壯類緣物(vardenafil analogue)成分，其結構經鑑定為2-(2-ethoxyphenyl)-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one。該食品檢體先以乙醇萃取，經管柱層析分離純化處理後，再由一維與二維核磁共振儀(1H-NMR, 13CNMR,COSY, DEPT, HMQC, HMBC)及高效液相串聯式質譜儀鑑定其結構，並確認為樂威壯類緣物。此係首次發現之非法外添加樂威壯類緣物成分，為保障民眾健康，已將此成分列為非法摻加西藥例行檢查項目之一。
並列摘要
A vardenafil analogue was found to be added illegally into a dietary supplement marketed for erectile dysfunction. Its structure was determined as 2-(2-ethoxyphenyl)-5-methyl-7-propyl-imidazo[5,1-f ][1,2,4]triazin-4(3H)-one. The sample was extracted with ethanol and isolated by column chromatography. The structure was identified with a series of 1-D and 2-D NMR techniques and LC/MS/MS. Having compared with structure of vardenafil, the data showed that the ethylpiperazinyl and sulfonyl of vardenafil were removed from the phenyl group. Since its structure was similar to that of vardenafil, side effects of vardenafil might associate with this analogue. This vardenafil analogue has been included in the inspection list of illegal adulterants in Taiwan.
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