Chemical and Biological Study of the Residual Aerial Parts of Sesamum indicum L.

芝麻殘留地上部的化學及生物研究

Amal El-Sayed Khaleel ； Mariam Hussain Gonaid ； Ramzia Ismail El-Bagry ； Amany Ameen Sleem ； Marwan Shabana

《藥物食品分析》 15卷3期 (2007/09) Pp. 249-257

摘要

埃及產的芝麻在收集種子之後，進行殘留地上部的化學研究。經由乙醇萃取步驟，芝麻素、芝麻素酚、豆甾醇、β-sitosterol及stigmasterol-3-O-β-Dglucoside於石油醚層被分離出。阿魏酸、鼠李素、verbascoside、kaempferol-3-O-β-D-glucuronide及mequelianin(quercetin-3-O-β-D-glucuronide)於丁醇層被分離出。主要成分－芝麻素及芝麻素酚，乃是利用HPLC檢測含量。乙醇萃取物、石油醚層及丁醇層部分進行體內試驗，包括抗氧化、防高血糖及抗凝血活性。結果顯示，在所測試的生物活性中，乙醇萃取物均較石油醚層及丁醇層部分有較高的活性。

關鍵字

芝麻 ； 殘留地上部 ； 木酚素 ； 黃酮類 ； 固醇類 ； 抗氧化 ； 防高血糖 ； 抗凝血活性

並列摘要

The chemical composition of the residual aerial parts of the Egyptian crop of Sesamum indicum L. after collection of the seeds, was studied. Sesamin, sesamolin, stigmasterol, β-sitosterol and stigmasterol-3-O-β-D-glucoside were isolated from the petroleum ether fraction of the alcoholic extract. Ferulic acid, rhamnetin, verbascoside, kaempferol-3-O-β-D-glucuronide and mequelianin (quercetin-3-O-β-D-glucuronide) were isolated from the butanol fraction. The content of the major constituents, namely sesamin and sesamolin, were determined by HPLC method. The alcoholic extract as well as its petroleum ether and butanol fractions were tested in vivo for the antioxidant, antihyperglycaemic and anticoagulant activities. The alcoholic extract exhibited a higher activity than its petroleum ether and butanol fractions in all the tested biological activities.

並列關鍵字

Sesamum indicum ； residual aerial parts ； lignans ； flavonoids ； sterols ； antioxidant ； anticoagulant ； antihyperglycaemic activity