Metastasis to the thyroid gland is rare, despite the rich vascular supply. Thyroid metastasis from lung carcinoma indicates a poor prognosis, and the average survival is 2 months. We report a 44-year-old woman with adenocarcinoma of the lung metastatic to the thyroid that responded poorly to tyrosine kinase inhibitor (TKI) target therapy. Ultimately, the patient succumbed to her disease.