The spinal cord injury (SCI) often follows accidental and unexpected events and always brings catastrophic impacts on physiologic, psychological, social, and spiritual dimensions to patients unexpectedly. SCI effortlessly causes many strains, such as hopelessness for mal-adaptation, and then influences related treatments and prognoses, even produces high suicide rates. Therefore, it is critical for nurses to attend and intervene before suicide occurs. The purpose of this case study was to explore the effectiveness of religion therapy on a mid-thirties lady with SCI. Data were collected via interviews, observations, history taking, and applications of the Nowotny Hope Scale (NHS; Nowotny, 1989) and found the major problem for the SCI patient was serious hopelessness. Using therapeutic communication skills to encourage her to disclose feelings and thoughts gradually, the patient's emotional distress was relaxed and psychological stress was improved. Her coping processes were successful in establishing a peaceful mind, in adopting an individualized care plan with religion and in looking forward to the future progressively. The religion therapy has to be utilized continuously to assist the patient to fit into the conformity with the disease course and to instill hope for the dawning of her brand-new life actively.