A Negative Study of the Association between Tumor Necrosis Factor Alpha-308G/A Polymorphism and Schizophrenia among Taiwanese Patients

精神分裂症與腫瘤壞死因子之基因多型性分析

黃隆正(Lung-Cheng Huang) ； 劉智民(Chih-Min Liu) ； 胡海國(Hai-Gwo Hwu)

《台灣精神醫學》 22卷2期 (2008/06) Pp. 141-147

https://doi.org/10.29478/TJP.200806.0007

摘要

目的：研究腫瘤壞死因子(TNF-α)基因之－308G/A單核酸多型性與精神分裂症之相關性。方法：本研究採用病例－對照相關研究法，及家系關聯性分析研究法來分析TNF-α基因－308G/A單核酸多型性與精神分裂症之相關性。病例－對照相關研究組包括124名病人及119名對照組；家系關聯性分析研究組包括80名病人，149名父母，及42名健康手足。結果：病例－對照相關研究的結果顯示，在TNF-α基因之－308G/A單核酸多型性上，精神分裂症與對照組之間其對偶基因頻率或基因型頻率並沒有任何差異；在家系關聯性分析研究中，亦未發現此一單核酸多型性有傳遞不平衡之現象。結論：本研究顯示TNF-α基因之－308G/A單核酸多型性在台灣精神分裂症的病源學上並不扮演決定性角色。

關鍵字

關聯研究 ； 單核酸多型性 ； 精神分裂症 ； 腫瘤壞死因子

並列摘要

Objectives: Tumor necrosis factor alpha (TNF-α) has been related to the pathogenesis of schizophrenia through its involvement in the processes of neurodevelopment and neurodegeneration. We examined the association between the TNF-α -308G/A polymorphism and schizophrenia in Taiwanese samples. Methods: The association analysis was performed using both a case-control and a family- based association design. The case-control sample comprised 124 patients and 119 controls; the family-based sample included 80 parent-offspring trio families. Results: No signifi cant difference was found in genotype or allele frequencies between patients with schizophrenia and controls. No signifi cant transmission distortion of the polymorphism was found in the family sample. Conclusion: Our results suggest that -308 G/A polymorphism in the TNF-α gene does not confer increased susceptibility to schizophrenia in this population of Han Chinese ethnicity from Taiwan.

並列關鍵字

association ； polymorphism ； schizophrenia ； tumor necrosis factor alpha

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