Metabolic Effects of Paliperidone in a Patient with Schizophrenia

使用Paliperidone治療精神分裂症病人所產生的代謝副作用

許雅芬(Ya-Fen Hsu) ； 張震霖(Chen-Lin Chang)

《台灣精神醫學》 26卷2期 (2012/06) Pp. 138-141+6

https://doi.org/10.29478/TJP.201206.0011

摘要

目的：使用第二代抗精神病劑治療精神分裂症具較佳療效。然而，它所產生運動障礙和代謝相關副作用是被廣泛擔憂的。較少報告提及第二代抗精神病劑paliperdone所產生的相關副作用，已知較常發生的藥物副作用包含錐體外症狀、頭痛、失眠、嗜睡和體重增加。本文提出一位精神分裂症病人以paliperidone治療後關於代謝副作用的臨床發現。病例報告：一位33歲男性病人於一年多前開始患有精神病症狀，此病人的精神病正性症狀，在paliperidone適當治療劑量和治療時程後，治療反應良好。但是，病人於治療一年期間體重由69.5公斤增至96.4公斤，且有高血脂和高尿酸血症之其他代謝副作用。病人主訴因代謝副作用而影響服藥順從性。結論：精神科醫師需要密切注意paliperidone治療後所產生的代謝副作用，並且應盡力預防或減少發生的可能性。

關鍵字

第二代抗精神病藥物 ； paliperidone ； 體重增高 ； 代謝症候群 ； 精神分裂症

並列摘要

Objective: Second-generation antipsychotic (SGA) drugs have a favorable therapeutic beneficial profile in patients with schizophrenia. But, we have more concerns about their adverse events in metabolic effects, which are less studied in paliperidone, an SGA. Its reported side effects include extrapyramidal symptoms, headache, insomnia, and somnolence as well as weight gain. Here, we report a patient with schizophrenia who was treated with paliperidone and developed metabolic effects. Case Report: More than one year ago, 33 -year-old male patient with schizophrenia had psychotic symptoms and received paliperidone. He responded well to paliperidone and he was maintained with at adequate dosage and duration. His body weight was increased from 69.5 kg to 96.4 kg after one-year treatment. His other metabolic effects included dyslipidemia and hyperuricemia. But he had poor drug compliance after development of metabolic effects. Conclusion: Psychiatrists should be cautious about the possibility of having paliperidone-induced metabolic effects. Efforts on psychoeducation should be made to prevent or minimize the adverse effects.

並列關鍵字

Second-generation antipsychotic drug ； paliperidone ； metabolic syndrome ； schizophrenia

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