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Piperacillin／tazobactam引起發燒、白血球及血小板低下之案例報告
CASE REPORT OF PIPERACILLIN/TAZOBACTAM INDUCING FEVER, LEUKOPENIA AND THROMBOCYTOPENIA
摘要
Piperacillin/tazobactam 為廣效抗生素，常見副作用為腸胃症狀及過敏反應，少有血液方面（＜1%）副作用。本文提出案例為76 歲男性患者，投與piperacillin/tazobactam治療肺炎，第11 天後出現高燒（38.3℃），第13 天後發現白血球及血小板低下（WBC: 2.95×103/ uL; PLT:14 ×1000/ uL），當停用piperacillin/tazobactam 10天後白血球及血小板值恢復到正常值。本案例報告旨在提醒療照護人員，臨床上長期使用piperacillin/tazobactam 需定期監測血液學變化，以確保病患用藥安全。
並列摘要
Piperacillin/tazobactam is used due to its broad antibacterial activity, and the most common adverse effects of this drug are gastrointestinal symptoms and skin reactions. Hematologic side effects are rare (＜1%). Here we report a case of 76-year old man, who developed fever (38.3°C) 11 days later and thrombocytopenia (PLT:14 ×1000/ uL) 13 days after treatment with piperacillin/tazobactam for pneumonia. The patient's platelet number returned to normal following withdrawal of piperacillin/tazobactam 10 days later. This case of adverse drug reaction warrants caution for caregivers to regularly monitor hematologic changes so as to ensure patient medication safety when using piperacillin/tazobactam.
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