Chest pain is one of the most common complaints in the emergency department (ED). Emergency physicians focus on the immediate recognition and exclusion of life-threatening causes of chest pain. However, vertebrogenic pain localized in the anterior thorax can imitate pain related to potentially life-threatening events. Paraspinal abscess of the cervical spine is rare. Early and accurate diagnosis of spinal infections leads to prompt treatment and a favorable outcome for the patient. Herein, we report a 46-year-old male patient with a paraspinal abscess of the cervical spine presenting with chest pain initially, followed by quadriplegia in the ED. Emergency physicians should maintain a high index of suspicion for this disease when treating patients with acute chest pain with acute onset of quadriplegia.